An ecofriendly and practical method for the efficient synthesis of various sulfonylated N-heteroaromatics in water under metal-free, organic-solvent-free, neutral, and mild reaction conditions was developed. The employment of readily available reagents, wide substrate scope, high chemoselectivity, and regioselectivity make this protocol very practical. Importantly, the pure products can be easily obtained via filtration and washing by alcohol without extraction and recrystallization.

Waste-Minimized Protocol for the Synthesis of Sulfonylated N-Heteroaromatics in Water

Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines.

Ultrasound-Assisted Multicomponent Reactions, Organometallic and Organochalcogen Chemistry

http://rua.ua.es/dspace/bitstream/10045/92590/2/2019_Dondas_etal_Organometallics_revised.pdf

Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo- and Heterocycles

Comprehensive Strategies for the Synthesis of Isoquinolines: Progress Since 2008

Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids

Palladium-Catalyzed Cascade Reaction of o-Cyanobiaryls with Arylboronic Acids: Synthesis of 5-Arylidene-7-aryl-5H-dibenzo[c,e]azepines.

Palladium‐Catalyzed Selective Synthesis of Dibenzo[c,e]azepin‐5‐ols and Benzo[c]pyrido[2,3‐e]azepin‐5‐ols

An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.

Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles.

Rongalite® promotes cleavage of diaryl disulphides generating the corresponding thiolate species in situ which then undergo facile ring-opening of epoxides in a regioselective manner under ultrasound irradiation, affording β-hydroxy sulphides in good to excellent yields The important features of this methodology are base-free, odourless, high yield, reasonably rapid reaction rate, simple workup, high regioselectivity, cost-effective and no requirement of transition metal catalysts It is noteworthy that ring-opening reaction of 1,2-diphenyldiselane with 2-(phenoxymethyl)oxirane are also conducted smoothly to afford β-hydroxy selenide in excellent yield under the standard conditions

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Tianxing Cheng

Papers

Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids

Palladium-Catalyzed Cascade Reaction of o-Cyanobiaryls with Arylboronic Acids: Synthesis of 5-Arylidene-7-aryl-5H-dibenzo[c,e]azepines.

Palladium‐Catalyzed Selective Synthesis of Dibenzo[c,e]azepin‐5‐ols and Benzo[c]pyrido[2,3‐e]azepin‐5‐ols

Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles.

Tandem base-free synthesis of β -hydroxy sulphides under ultrasound irradiation