Tigwa H. Davis

TL;DR: In vivo studies of Dicer and miRNAs provide additional support for previous in vitro studies indicating that misregulation of this pathway may result in gross abnormalities in cell number and function that may contribute to a variety of neurological disorders.

TL;DR: It is shown that dopaminoceptive neurons without Dicer survive over the life of the animal and the lack of profound cell death contrasts with other mouse models in which Dicer has been ablated.

TL;DR: The results suggest that β1-mediated neurite outgrowth occurs through a lipid raft signaling mechanism that requires the presence of both fyn kinase and contactin, and concludes that voltage-gated Na+ channel β1 subunits signal via multiple pathways on multiple timescales and play important roles in the postnatal development of the CNS.

TL;DR: It is demonstrated that homophilic interactions between voltage-gated sodium channel β1 subunits promote neurite extension in cerebellar granule neurons, suggesting a novel role for β1 during neuronal development and the first demonstration of a functional role for sodium channelβ subunit-mediated cell adhesive interactions.

TL;DR: It is demonstrated that a single cysteine-to-alanine substitution at extracellular residue Cys-26, located within the immunoglobulin (Ig) domain, abolishes the covalent linkage between α and β2 subunits.