T
Tim Crook
Researcher at Imperial College London
Publications - 69
Citations - 5503
Tim Crook is an academic researcher from Imperial College London. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 36, co-authored 69 publications receiving 5118 citations. Previous affiliations of Tim Crook include Thomas Jefferson University & The Breast Cancer Research Foundation.
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Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation.
TL;DR: It is shown that E 6 proteins of both oncogenic and benign HPV types associate in vitro with p53, but binding by E6 proteins of benign HPVtypes cannot target p53 for degradation, and a C-terminal region of E6 conserved among all HPV types is important for p53 binding.
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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.
Barbara Delage,Dean A. Fennell,Linda J. Nicholson,Iain A. McNeish,Iain A. McNeish,Nicholas R. Lemoine,Nicholas R. Lemoine,Tim Crook,Peter W. Szlosarek,Peter W. Szlosarek +9 more
TL;DR: The prospects for novel approaches in the prevention, diagnosis and treatment of malignant disease based on ASS1 pathophysiology and its rate‐limiting product, arginine are examined.
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Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours
TL;DR: The data indicate that loss of wild-type p53 function is important in the pathology of cervical cancer and that in the absence of an HPV-encoded gene product that mediates loss of p53function, somatic mutation of the gene is required.
Journal Article
p53 point mutation in HPV negative human cervical carcinoma cell lines.
TL;DR: The data suggest that loss of wild-type p53 function is important in development of cervical carcinoma, and that this might be achieved either by mutation within the p53 gene or the presence of a virally encoded p53 binding protein.
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A Pin1/mutant p53 axis promotes aggressiveness in breast cancer.
Javier E. Girardini,Javier E. Girardini,Marco Napoli,Marco Napoli,Silvano Piazza,Alessandra Rustighi,Alessandra Rustighi,Carolina Marotta,Carolina Marotta,Enrico Radaelli,Valeria Capaci,Valeria Capaci,Lee B. Jordan,Phil Quinlan,Alastair M. Thompson,Alastair M. Thompson,Miguel Mano,Antonio Rosato,Tim Crook,Eugenio Scanziani,Anthony R. Means,Guillermina Lozano,Claudio Schneider,Claudio Schneider,Giannino Del Sal,Giannino Del Sal +25 more
TL;DR: A Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers is defined and a transcriptional signature associated with poor prognosis in breast cancer and Pin1 overexpression influenced the prognostic value of p53 mutation is identified.