T
Tim H M Huang
Researcher at University of Texas Health Science Center at San Antonio
Publications - 329
Citations - 21592
Tim H M Huang is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 80, co-authored 318 publications receiving 19905 citations. Previous affiliations of Tim H M Huang include Indiana University & University of Texas at Austin.
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Journal ArticleDOI
Identification and characterization of ovarian cancer-initiating cells from primary human tumors.
Shu Zhang,Curt Balch,Michael W.Y. Chan,Hung Cheng Lai,Daniela Matei,Jeanne M. Schilder,Pearlly S. Yan,Tim H M Huang,Kenneth P. Nephew +8 more
TL;DR: It is asserted that epithelial ovarian cancers derive from a subpopulation of CD44(+)CD117(+) cells, thus representing a possible therapeutic target for this devastating disease.
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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Yutaka Kondo,Lanlan Shen,Alfred S. L. Cheng,Alfred S. L. Cheng,Saira Ahmed,Yanis Boumber,Chantale Charo,Tadanori Yamochi,Takeshi Urano,Koichi Furukawa,Bernard Kwabi-Addo,David Gold,Yoshitaka Sekido,Tim H M Huang,Jean Pierre J. Issa +14 more
TL;DR: Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation.
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Methylation Profiling of CpG Islands in Human Breast Cancer Cells
TL;DR: This study provides evidence that, aside from random DNA-MTase action, additional cellular factors exist that govern aberrant methylation in breast cancer cells.
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Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
TL;DR: It is suggested that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors.
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The functional consequences of alternative promoter use in mammalian genomes
Ramana V. Davuluri,Ramana V. Davuluri,Yutaka Suzuki,Sumio Sugano,Christoph Plass,Christoph Plass,Tim H M Huang +6 more
TL;DR: The functional consequences of use and misuse of alternative promoters in normal and disease genomes are discussed and the molecular mechanisms regulating alternative promoter use in mammalian genomes are reviewed.