T
Timothy Lynch
Researcher at University College Dublin
Publications - 140
Citations - 11076
Timothy Lynch is an academic researcher from University College Dublin. The author has contributed to research in topics: Parkinsonism & Parkinson's disease. The author has an hindex of 46, co-authored 130 publications receiving 10324 citations. Previous affiliations of Timothy Lynch include Mater Misericordiae Hospital & Mater Misericordiae University Hospital.
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Journal ArticleDOI
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Mike Hutton,Corinne Lendon,Patrizia Rizzu,Matt Baker,Susanne Froelich,Susanne Froelich,Henry Houlden,Stuart Pickering-Brown,Sumitra Chakraverty,Adrian M. Isaacs,Andrew Grover,J. Hackett,Jennifer Adamson,Sarah Lincoln,Dennis W. Dickson,Peter Davies,Ronald C. Petersen,M. Stevens,E. De Graaff,E. Wauters,J. Van Baren,M. Hillebrand,Marijke Joosse,J. M. Kwon,Petra Nowotny,Lien Kuei Che,Joanne Norton,John C. Morris,L. A. Reed,John Q. Trojanowski,Hans Basun,Lars Lannfelt,M. Neystat,Stanley Fahn,Frances Dark,Tony Tannenberg,Peter R. Dodd,Nicholas K. Hayward,John B.J. Kwok,Peter R. Schofield,Athena Andreadis,Julie S. Snowden,David Craufurd,David Neary,F. Owen,Ben A. Oostra,John Hardy,Alison Goate,J. C. van Swieten,David M. A. Mann,Timothy Lynch,Peter Heutink +51 more
TL;DR: In this paper, the authors sequenced tau in FTDP-17 families and identified three missense mutations (G272V, P301L and R406W) and three mutations in the 5' splice site of exon in
Journal ArticleDOI
VPS35 Mutations in Parkinson Disease
Carles Vilariño-Güell,Christian Wider,Owen A. Ross,Justus C. Dachsel,Jennifer M. Kachergus,Sarah Lincoln,Alexandra I. Soto-Ortolaza,Stephanie A. Cobb,Greggory J. Wilhoite,Justin A. Bacon,Behrouz Bahareh Behrouz,Heather L. Melrose,Emna Hentati,Andreas Puschmann,Andreas Puschmann,Daniel M. Evans,Elizabeth Conibear,Wyeth W. Wasserman,Jan O. Aasly,Pierre R. Burkhard,Ruth Djaldetti,Joseph Ghika,Fayçal Hentati,Anna Krygowska-Wajs,Timothy Lynch,Timothy Lynch,Eldad Melamed,Alex Rajput,Ali H. Rajput,Alessandra Solida,Ruey-Meei Wu,Ryan J. Uitti,Zbigniew K. Wszolek,François Vingerhoets,Matthew J. Farrer,Matthew J. Farrer +35 more
TL;DR: This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD.
Journal ArticleDOI
Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations
Jennifer M. Kachergus,Ignacio F. Mata,Mary M. Hulihan,Julie P. Taylor,Sarah Lincoln,Jan O. Aasly,J. Mark Gibson,Owen A. Ross,Timothy Lynch,Timothy Lynch,Joseph Wiley,Joseph Wiley,Haydeh Payami,John G. Nutt,Demetrius M. Maraganore,Krzysztof Czyzewski,Maria Styczyńska,Zbigniew K. Wszolek,Matthew J. Farrer,Mathias Toft +19 more
TL;DR: It is demonstrated that LRRK2 G2019S accounts for parkinsonism in several families within Europe and North America, highlighting the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis.
Journal Article
Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22
TL;DR: It is suggested that the DDPAC locus should be screened as a candidate locus in family studies of conditions with behavioral abnormalities and neurological degeneration.
Journal ArticleDOI
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
Sruti Rayaprolu,Bianca Mullen,Matt Baker,Timothy Lynch,Elizabeth Finger,William W. Seeley,Kimmo J. Hatanpaa,Catherine Lomen-Hoerth,Andrew Kertesz,Eileen H. Bigio,Carol F. Lippa,Keith A. Josephs,David S. Knopman,Charles L. White,Richard J. Caselli,Ian R. A. Mackenzie,Bruce L. Miller,Magdalena Boczarska-Jedynak,Grzegorz Opala,Anna Krygowska-Wajs,Maria Barcikowska,Steven G. Younkin,Ronald C. Petersen,Nilufer Ertekin-Taner,Ryan J. Uitti,James F. Meschia,Kevin B. Boylan,Bradley F. Boeve,Neill R. Graff-Radford,Zbigniew K. Wszolek,Dennis W. Dickson,Rosa Rademakers,Owen A. Ross +32 more
TL;DR: The results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer’s disease, and suggest a more general role for TREM 2 dysfunction in neurodegeneration, which could be related to its role in the immune response.