T
Timothy M. Palmer
Researcher at Hull York Medical School
Publications - 88
Citations - 4365
Timothy M. Palmer is an academic researcher from Hull York Medical School. The author has contributed to research in topics: Receptor & Adenosine receptor. The author has an hindex of 39, co-authored 83 publications receiving 3832 citations. Previous affiliations of Timothy M. Palmer include Duke University & University of Bradford.
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Journal ArticleDOI
Regulating gene transcription in response to cyclic AMP elevation
TL;DR: Both PKA-dependent and -independent mechanisms that have been proposed to explain how cAMP influences the activation status of multiple transcription factors, and how these influence critical biological processes whose defective regulation may lead to disease are discussed.
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Triage of HPV positive women in cervical cancer screening.
TL;DR: An optimal integrated screening and triage strategy should reassure the vast majority of women that they are at very low risk of cervical cancer, send the women at highest risk to colposcopy at the right time, when disease can be colposcopically detected, and minimize the intermediate risk group that requires continued surveillance.
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Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study
Kimberley Kavanagh,Kevin G.J. Pollock,Kate Cuschieri,Timothy M. Palmer,Ross L. Cameron,D. Cameron Watt,Ramya Bhatia,Catherine Moore,Heather Cubie,Margaret E. Cruickshank,Chris Robertson,Chris Robertson +11 more
TL;DR: Bivalent vaccination has led to a startling reduction in vaccine and cross-protective HPV types 7 years after vaccination, and should be considered in cost-effectiveness models informing vaccine choice and models to shape the future of cervical screening programmes.
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Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
Forbes Alderton,Soma Rakhit,Kok Choi Kong,Timothy M. Palmer,Balwinder Sambi,Susan Pyne,Nigel J. Pyne +6 more
TL;DR: A tethered receptor complex provides a platform on which receptor tyrosine kinase and G-protein-coupled receptor signals can be integrated to produce more efficient stimulation of the p42/p44 mitogen-activated protein kinase pathway.
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Exchange Protein Activated by Cyclic AMP (Epac)-Mediated Induction of Suppressor of Cytokine Signaling 3 (SOCS-3) in Vascular Endothelial Cells
TL;DR: The existence of a novel cAMP/Epac/Rap1/SOCS-3 pathway for limiting IL-6 receptor signaling in ECs is argued for and a new mechanism by which cAMP may mediate its potent anti-inflammatory effects is illuminated.