Timothy Roach

TL;DR: Data show that the process of accumulation of escape mutations within HIV is not inevitable, and complex epitope- and residue-specific selection forces, including CTL-mediated positive selection pressure and virus-mediated purifying selection, operate in tandem to shape HIV evolution at the population level.

TL;DR: Factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations are identified.

TL;DR: Analysis of cytotoxic T lymphocyte responses restricted by HLA-B*1503 suggests that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination ofSubdominant yet effective epitopes from circulating viral populations.

TL;DR: HLA-B63-positive subjects generated responses early in acute HIV infection and were able to control HIV replication in the absence of antiretroviral treatment and help to better define immune correlates of controlled HIV infection.

TL;DR: All tested centralized antigens provided a similarly potent set of antigenic peptides, and the significantly broader responses detected using the combination of sets highlight the importance of maximizing coverage of HIV-1 sequence diversity in vaccine preparations, as well as in the evaluation of CTL responses in HIV- 1-infected individuals and those vaccinated.