T
Tin-Yun Ho
Researcher at China Medical University (Taiwan)
Publications - 114
Citations - 4096
Tin-Yun Ho is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: In vivo & Gene expression. The author has an hindex of 34, co-authored 109 publications receiving 3413 citations. Previous affiliations of Tin-Yun Ho include Asia University (Taiwan).
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Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.
Cheng Wen Lin,Fuu Jen Tsai,Chang Hai Tsai,Chien-Chen Lai,Lei Wan,Tin-Yun Ho,Chang Chi Hsieh,Pei-Dawn Lee Chao +7 more
TL;DR: The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development.
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Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
TL;DR: Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner and suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.
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Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats.
TL;DR: FA provides neuroprotection against oxidative stress-related apoptosis by inhibiting ICAM-1 mRNA expression after cerebral ischemia/reperfusion injury in rats, suggesting that FA provides neuroprotective effects of FA during reperfusion after cerebral waschemia.
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Ferulic acid reduces cerebral infarct through its antioxidative and anti-Inflammatory effects following transient focal cerebral ischemia in rats
TL;DR: Results showed that the effect of FA on reducing cerebral infarct area and neurological deficit-score were at least partially attributed to the inhibition of superoxide radicals, ICAM-1 and NF-kappaB expression in transient MCAo rats.
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5-Fluorouracil induced intestinal mucositis via nuclear factor-κB activation by transcriptomic analysis and in vivo bioluminescence imaging.
Chung Ta Chang,Chung Ta Chang,Tin-Yun Ho,Ho Lin,Ji An Liang,Hui-Chi Huang,Chia-Cheng Li,Hsin Yi Lo,Shih Lu Wu,Yi Fang Huang,Chien-Yun Hsiang +10 more
TL;DR: It is suggested that NF-κB was the critical molecule associated with the pathogenesis of 5-FU-induced mucositis, and inhibition of NF-σB activity ameliorated the mucosal damage caused by 5-Fluorouracil.