Ting-Yu Lin

Bio: Ting-Yu Lin is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Network packet & Medicine. The author has an hindex of 23, co-authored 70 publications receiving 1346 citations. Previous affiliations of Ting-Yu Lin include National Yang-Ming University & Cornell University.

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Abstract: Activating mutations in PIK3CA are frequent in human breast cancer, and phosphoinositide 3-kinase alpha (PI3Kα) inhibitors have been approved for therapy. To characterize determinants of sensitivity to these agents, we analyzed PIK3CA-mutant cancer genomes and observed the presence of multiple PIK3CA mutations in 12 to 15% of breast cancers and other tumor types, most of which (95%) are double mutations. Double PIK3CA mutations are in cis on the same allele and result in increased PI3K activity, enhanced downstream signaling, increased cell proliferation, and tumor growth. The biochemical mechanisms of dual mutations include increased disruption of p110α binding to the inhibitory subunit p85α, which relieves its catalytic inhibition, and increased p110α membrane lipid binding. Double PIK3CA mutations predict increased sensitivity to PI3Kα inhibitors compared with single-hotspot mutations.

Interplay of Spatial Reuse and SINR-Determined Data Rates in CSMA/CA-Based, Multi-Hop, Multi-Rate Wireless Networks

Abstract: In CSMA/CA-based, multi-hop, multi-rate wireless networks, spatial reuse can be increased by tuning the carrier-sensing threshold (Tcs) to reduce the carrier sense range (dcs). While reducing dcs enables more concurrent transmissions, the transmission quality suffers from the increased accumulative interference contributed by concurrent transmissions outside dcs. As a result, the data rate at which the transmission can sustain may decrease. How to balance the interplay of spatial reuse and transmission quality (and hence the sustainable data rate) so as to achieve high network capacity is thus an important issue. In this paper, we investigate this issue by extending Cali's model and devising an analytical model that characterizes the transmission activities as governed by IEEE 802.11 DCF in a single-channel, multi-rate, multi-hop wireless network. The systems throughput is derived as a function of Tcs, SINR, beta, and other PHY/MAC systems parameters. We incorporate the effect of varying the degree of spatial reuse by tuning the Tcs. Based on the physical radio propagation model, we theoretically estimate the potential accumulated interference contributed by concurrent transmissions and the corresponding SINR. For a given SINR value, we then determine an appropriate data rate at which a transmission can sustain. To the best of our knowledge, this is perhaps the first effort that considers tuning of PHY characteristics (transmit power and data rates) and MAC parameters (contention backoff timer) jointly in an unified framework in order to optimize the overall network throughput. Analytical results indicate that the systems throughput is not a monotonically increasing/decreasing function of Tcs, but instead exhibits transitional points where several possible choices of Tcs can be made. In addition, the network capacity can be further improved by choosing the backoff timer values appropriately.

A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly

Abstract: DNA aptamers have potential for disease diagnosis and as therapeutics, particularly when interfaced with programmable molecular technology. Here we have combined DNA aptamers specific for the malaria biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) with a DNA origami scaffold. Twelve aptamers that recognise PfLDH were integrated into a rectangular DNA origami and atomic force microscopy demonstrated that the incorporated aptamers preserve their ability to specifically bind target protein. Captured PfLDH retained enzymatic activity and protein-aptamer binding was observed dynamically using high-speed AFM. This work demonstrates the ability of DNA aptamers to recognise a malaria biomarker whilst being integrated within a supramolecular DNA scaffold, opening new possibilities for malaria diagnostic approaches based on DNA nanotechnology.

Random graphs

Abstract: We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Fundamentals of Queueing Theory

Abstract: Praise for the Third Edition: "This is one of the best books available. Its excellent organizational structure allows quick reference to specific models and its clear presentation . . . solidifies the understanding of the concepts being presented."IIE Transactions on Operations EngineeringThoroughly revised and expanded to reflect the latest developments in the field, Fundamentals of Queueing Theory, Fourth Edition continues to present the basic statistical principles that are necessary to analyze the probabilistic nature of queues. Rather than presenting a narrow focus on the subject, this update illustrates the wide-reaching, fundamental concepts in queueing theory and its applications to diverse areas such as computer science, engineering, business, and operations research.This update takes a numerical approach to understanding and making probable estimations relating to queues, with a comprehensive outline of simple and more advanced queueing models. Newly featured topics of the Fourth Edition include:Retrial queuesApproximations for queueing networksNumerical inversion of transformsDetermining the appropriate number of servers to balance quality and cost of serviceEach chapter provides a self-contained presentation of key concepts and formulae, allowing readers to work with each section independently, while a summary table at the end of the book outlines the types of queues that have been discussed and their results. In addition, two new appendices have been added, discussing transforms and generating functions as well as the fundamentals of differential and difference equations. New examples are now included along with problems that incorporate QtsPlus software, which is freely available via the book's related Web site.With its accessible style and wealth of real-world examples, Fundamentals of Queueing Theory, Fourth Edition is an ideal book for courses on queueing theory at the upper-undergraduate and graduate levels. It is also a valuable resource for researchers and practitioners who analyze congestion in the fields of telecommunications, transportation, aviation, and management science.