Nickel-phosphine complex-catalyzed Grignard coupling—II : Grignard coupling of heterocyclic compounds

Selective cross-coupling reactions between C(sp3) and C(sp2) centers had been one of the most difficult tasks in carbon–carbon bond synthesis until the early 1970s, when it was first reported that iron,1,2 nickel,3,4 palladium5 and copper2,6 catalysts are extremely effective for cross-coupling of Grignard reagents with organic halides. Now, nearly 20 years later, transition metal catalyzed cross-coupling has become the reaction of first choice for this purpose.

Coupling Reactions Between sp 3 and sp 2 Carbon Centers

An efficient method for the cross-coupling of primary trialkylbismuth compounds with 2-haloazines- and -diazines, that tolerates various functional groups is developed.

Tiziano Martinengo

Papers

Nickel Catalyzed Alkylation of 2-Chloro-Pyridine. A Facile Synthesis of ω-(2-Pyridyl)-Alkylic Alcohols