T
Tobias C. Walther
Researcher at Harvard University
Publications - 150
Citations - 25535
Tobias C. Walther is an academic researcher from Harvard University. The author has contributed to research in topics: Lipid droplet & Endoplasmic reticulum. The author has an hindex of 61, co-authored 140 publications receiving 21497 citations. Previous affiliations of Tobias C. Walther include Southern Methodist University & European Bioinformatics Institute.
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Journal ArticleDOI
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary,Chanchal Kumar,Florian Gnad,Michael L. Nielsen,Michael Rehman,Tobias C. Walther,Jesper V. Olsen,Matthias Mann +7 more
TL;DR: A proteomic-scale analysis of protein acetylation suggests that it is an important biological regulatory mechanism and the regulatory scope of lysine acetylations is broad and comparable with that of other major posttranslational modifications.
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Cellular fatty acid metabolism and cancer
TL;DR: Evidence that limiting fatty acid availability can control cancer cell proliferation is summarized, and a view of cancer cell metabolism from a lipid perspective is provided.
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Lipid Droplets and Cellular Lipid Metabolism
TL;DR: The current knowledge of LD cell biology and its translation to physiology is reviewed, finding that many aspects of LD biology are unknown.
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The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
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Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast.
Lyris M. F. de Godoy,Jesper V. Olsen,Jürgen Cox,Michael L. Nielsen,Nina C. Hubner,Florian Fröhlich,Tobias C. Walther,Matthias Mann +7 more
TL;DR: Comparison of protein levels of essentially all endogenous proteins in haploid yeast cells to their diploid counterparts spans more than four orders of magnitude in protein abundance with no discrimination against membrane or low level regulatory proteins.