T
Tobias Fehlmann
Researcher at Saarland University
Publications - 97
Citations - 4625
Tobias Fehlmann is an academic researcher from Saarland University. The author has contributed to research in topics: microRNA & RNA. The author has an hindex of 23, co-authored 89 publications receiving 2430 citations.
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Journal ArticleDOI
Distribution of miRNA expression across human tissues
Nicole Ludwig,Petra Leidinger,Kurt Becker,Christina Backes,Tobias Fehlmann,Christian P. Pallasch,Steffi Rheinheimer,Benjamin Meder,Cord F. Stähler,Eckart Meese,Andreas Keller +10 more
TL;DR: A human miRNA tissue atlas is presented by determining the abundance of 1997 miRNAs in 61 tissue biopsies of different organs from two individuals collected post-mortem, revealing that tissues like several areas of the brain clustered together andMiRNAs that were highly abundant in certain human tissues were likewise abundant in according rat tissues.
Journal ArticleDOI
An estimate of the total number of true human miRNAs.
Julia Alles,Tobias Fehlmann,Ulrike Fischer,Christina Backes,Galata,Marie Minet,Martin Hart,Masood Abu-Halima,Friedrich A. Grässer,Hans-Peter Lenhof,Andreas Keller,Eckart Meese +11 more
TL;DR: The experimentally validated miRNAs will contribute to revising targetomes hypothesized by utilizing falsely annotated miRNA candidates, 1115 of which are currently annotated in miRBase V22.
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Dysregulation of brain and choroid plexus cell types in severe COVID-19.
Andrew C. Yang,Fabian Kern,Patricia Moran Losada,Maayan R. Agam,Christina A. Maat,Georges Pierre Schmartz,Tobias Fehlmann,Julian A. Stein,Nicholas Schaum,Davis P. Lee,Kruti Calcuttawala,Ryan T. Vest,Daniela Berdnik,Nannan Lu,Oliver Hahn,David Gate,M. Windy McNerney,Divya Channappa,Inma Cobos,Nicole Ludwig,Walter J. Schulz-Schaeffer,Andreas Keller,Andreas Keller,Tony Wyss-Coray +23 more
TL;DR: In this article, single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.
Journal ArticleDOI
PLSDB: a resource of complete bacterial plasmids
TL;DR: PLSDB is a resource containing 13 789 plasmid records collected from the NCBI nucleotide database that provides an interactive view of all obtained plasmids with additional meta information such as sequence characteristics, sample-related information and taxonomy.
Journal ArticleDOI
Ageing hallmarks exhibit organ-specific temporal signatures.
Nicholas Schaum,Benoit Lehallier,Oliver Hahn,Róbert Pálovics,Shayan Hosseinzadeh,Song E. Lee,Rene Sit,Davis P. Lee,Davis P. Lee,Patricia Moran Losada,Macy E. Zardeneta,Macy E. Zardeneta,Tobias Fehlmann,James T. Webber,Aaron McGeever,Kruti Calcuttawala,Hui Zhang,Daniela Berdnik,Vidhu Mathur,Weilun Tan,Alexander Zee,Michelle Tan,Angela Oliveira Pisco,Jim Karkanias,Norma Neff,Andreas Keller,Andreas Keller,Spyros Darmanis,Stephen R. Quake,Tony Wyss-Coray +29 more
TL;DR: Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.