T
Tobias Meyer
Researcher at Stanford University
Publications - 200
Citations - 29515
Tobias Meyer is an academic researcher from Stanford University. The author has contributed to research in topics: Signal transduction & Endoplasmic reticulum. The author has an hindex of 88, co-authored 192 publications receiving 27162 citations. Previous affiliations of Tobias Meyer include Duke University & University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
Jen Liou,Man Lyang Kim,Won Do Heo,Joshua T. Jones,Jason W. Myers,James E. Ferrell,Tobias Meyer +6 more
TL;DR: This study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(1+)-store-depletion-mediated Ca( 2+) influx, and suggests that this mutant failed to respond to store depletion.
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Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate
TL;DR: For a transient point source of messenger in cells smaller than 20 microns, IP3 is a global messenger, whereas Ca2+ acts in restricted domains.
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PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.
Won Do Heo,Takanari Inoue,Wei Sun Park,Man Lyang Kim,Byung Ouk Park,Thomas J. Wandless,Tobias Meyer +6 more
TL;DR: This work surveyed PM-targeting mechanisms by imaging the subcellular localization of 125 fluorescent protein–conjugated Ras, Rab, Arf, and Rho proteins and found that proteins with polybasic clusters dissociated from the PM only when both PI(4,5)P2 and phosphatidylinositol 3,4, 5-trisphosphate were depleted.
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Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells
TL;DR: The studies show that PtdIns(4,5)P2 can have second messenger functions of its own, by mediating a transient dissociation of proteins anchored in the plasma membrane.
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Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion
Drazen Raucher,Thomas P. Stauffer,Wen Chen,Kang Shen,Shuling Guo,John D. York,Michael P. Sheetz,Tobias Meyer +7 more
TL;DR: This study suggests that plasma membrane PIP2 controls dynamic membrane functions and cell shape by locally increasing and decreasing the adhesion between the actin-based cortical cytoskeleton and the plasma membrane.