T
Tobias S. Schiergens
Researcher at Ludwig Maximilian University of Munich
Publications - 88
Citations - 16714
Tobias S. Schiergens is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Hepatic stellate cell & Hepatectomy. The author has an hindex of 20, co-authored 86 publications receiving 11152 citations. Previous affiliations of Tobias S. Schiergens include Free University of Berlin & German Cancer Research Center.
Papers
More filters
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial
Markus K. Diener,Phillip Knebel,Meinhard Kieser,Philipp Schüler,Tobias S. Schiergens,Vladimir Atanassov,Jens Neudecker,Erwin Stein,Henryk Thielemann,Reiner Kunz,Moritz von Frankenberg,Utz Schernikau,Jörg Bunse,Boris Jansen-Winkeln,Lars Ivo Partecke,Gerald Prechtl,Julius Pochhammer,Ralf Bouchard,René Hodina,K Tobias E Beckurts,Lothar Leißner,Hans-Peter Lemmens,F. Kallinowski,Oliver Thomusch,Daniel Seehofer,Thomas Simon,Alexander Hyhlik-Dürr,Christoph M. Seiler,Thilo Hackert,Christoph Reissfelder,Rene Hennig,Colette Doerr-Harim,Christina Klose,Alexis Ulrich,Markus W. Büchler +34 more
TL;DR: Triclosan-coated PDS Plus did not reduce the occurrence of surgical site infection after elective midline abdominal laparotomy, and innovative, multifactorial strategies need to be developed and assessed in future trials to reduce surgical site infections.
Journal ArticleDOI
Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases.
Tobias S. Schiergens,Markus Rentsch,Michael S. Kasparek,Katharina Frenes,Karl-Walter Jauch,Wolfgang E. Thasler +5 more
TL;DR: In patients undergoing liver resection for colorectal liver metastases, perioperative transfusion is independently associated with earlier disease recurrence, including the conservative correction of preoperative anemia, the use of low transfusion triggers, and the minimization of intraoperative blood loss.
Journal ArticleDOI
Effects of low frequency electromagnetic fields on the chondrogenic differentiation of human mesenchymal stem cells.
Susanne Mayer-Wagner,Alice Passberger,Birte Sievers,Joachim Aigner,Burkhard Summer,Tobias S. Schiergens,Volkmar Jansson,Peter E. Müller +7 more
TL;DR: Chondrogenic differentiation of hMSCs may be improved by EMF regarding collagen type II expression and GAG content of cultures, and provide a new step in regenerative medicine regarding tissue engineering of cartilage.
Journal ArticleDOI
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
Wiebke Albrecht,Franziska Kappenberg,Tim Brecklinghaus,Regina Stoeber,Rosemarie Marchan,Mian Zhang,Kristina E Ebbert,Hendrik Kirschner,Marianna Grinberg,Marianna Grinberg,Marcel Leist,Wolfgang Moritz,Cristina Cadenas,Ahmed Ghallab,Ahmed Ghallab,Jörg Reinders,Nachiket Vartak,Christoph van Thriel,Klaus Golka,Laia Tolosa,José V. Castell,Georg Damm,Georg Damm,Daniel Seehofer,Daniel Seehofer,Alfonso Lampen,Albert Braeuning,Thorsten Buhrke,Anne Cathrin Behr,Axel Oberemm,Xiaolong Gu,Naim Kittana,Bob van de Water,Reinhard Kreiling,Susann Fayyaz,Leon van Aerts,Bård Smedsrød,Heidrun Ellinger-Ziegelbauer,Thomas Steger-Hartmann,Ursula Gundert-Remy,Anja Zeigerer,Anett Ullrich,Dieter Runge,Serene M. L. Lee,Tobias S. Schiergens,Lars Kuepfer,Alejandro Aguayo-Orozco,Agapios Sachinidis,Karolina Edlund,Iain Gardner,Jörg Rahnenführer,Jan G. Hengstler +51 more
TL;DR: An in vitro/in silico method was established that predicts the risk of human DILI in relation to oral doses and blood concentrations of test compounds to the probability of hepatotoxicity and application to the rat hepatotoxicant pulegone resulted in an ADI similar to values previously established based on animal experiments.