T
Toby C. Cornish
Researcher at University of Colorado Denver
Publications - 78
Citations - 11284
Toby C. Cornish is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Prostate cancer & Tumor microenvironment. The author has an hindex of 31, co-authored 76 publications receiving 9079 citations. Previous affiliations of Toby C. Cornish include Anschutz Medical Campus & Johns Hopkins University.
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Journal ArticleDOI
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Dung T. Le,Jennifer N. Uram,Hao Wang,Bjarne Bartlett,Holly Kemberling,Aleksandra Eyring,Andrew D. Skora,Brandon Luber,Nilofer S. Azad,Daniel A. Laheru,Barbara A. Biedrzycki,Ross C. Donehower,Atif Zaheer,George A. Fisher,Todd S. Crocenzi,James J. Lee,Steven M. Duffy,Richard M. Goldberg,Richard M. Goldberg,Albert de la Chapelle,Albert de la Chapelle,Minori Koshiji,Feriyl Bhaijee,Thomas Huebner,Ralph H. Hruban,Laura D. Wood,Nathan Cuka,Drew M. Pardoll,Nickolas Papadopoulos,Kenneth W. Kinzler,Shibin Zhou,Toby C. Cornish,Janis M. Taube,Robert A. Anders,James R. Eshleman,Bert Vogelstein,Luis A. Diaz +36 more
TL;DR: This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab, and high somatic mutation loads were associated with prolonged progression-free survival.
Journal ArticleDOI
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
Bora Gurel,Tsuyoshi Iwata,Cheryl M. Koh,Robert B. Jenkins,Fusheng Lan,Chi V. Dang,Jessica Hicks,James D. Morgan,Toby C. Cornish,Siobhan Sutcliffe,William B. Isaacs,Jun Luo,Angelo M. De Marzo +12 more
TL;DR: Evidence is provided that upregulation of nuclear MYC protein expression is a highly prevalent and early change in prostate cancer and suggest that increased nuclear Myc protein expression may be a critical oncogenic event driving human prostate cancer initiation and progression.
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Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma
Elizabeth D. Thompson,Marianna Zahurak,Adrian Murphy,Toby C. Cornish,Nathan Cuka,Eihab Abdelfatah,Stephen C. Yang,Mark D. Duncan,Nita Ahuja,Janis M. Taube,Robert A. Anders,Ronan J. Kelly +11 more
TL;DR: Surprisingly, it is demonstrated that increasing CD8 infiltration is correlated with impaired PFS and OS, and patients with higher CD8+ T cell densities also have higher PD-L1 expression, indicating an adaptive immune resistance mechanism may be occurring.
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DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
Srinivasan Yegnasubramanian,Michael C. Haffner,Yonggang Zhang,Bora Gurel,Toby C. Cornish,Zhijin Wu,Rafael A. Irizarry,James D. Morgan,Jessica Hicks,Theodore L. DeWeese,William B. Isaacs,G. Steven Bova,Angelo M. De Marzo,William G. Nelson +13 more
TL;DR: Evidence is provided that DNA hypomethylation changes occur later in prostate carcinogenesis than the CpG island hypermethylation changes and occur heterogeneously during prostate cancer progression and metastatic dissemination.
Journal ArticleDOI
PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Ashley Cimino-Mathews,Elizabeth D. Thompson,Janis M. Taube,Xiaobu Ye,Yao Lu,Alan K. Meeker,Haiying Xu,Rajni Sharma,Kristen Lecksell,Toby C. Cornish,Nathan Cuka,Pedram Argani,Leisha A. Emens +12 more
TL;DR: The data support PD-L1 expression by tumor cells as a biomarker of active breast tumor immunity and programmed death 1 blockade as a therapeutic strategy for breast cancer.