T
Todd B. Sherer
Researcher at Emory University
Publications - 47
Citations - 10146
Todd B. Sherer is an academic researcher from Emory University. The author has contributed to research in topics: Parkinson's disease & Rotenone. The author has an hindex of 28, co-authored 39 publications receiving 9464 citations. Previous affiliations of Todd B. Sherer include University of California, Berkeley & Michael J. Fox Foundation.
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Chronic systemic pesticide exposure reproduces features of Parkinson's disease
TL;DR: It is reported that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity.
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Mechanism of toxicity in rotenone models of Parkinson's disease.
Todd B. Sherer,Ranjita Betarbet,Claudia M. Testa,Byoung Boo Seo,Jason R. Richardson,Jin Ho Kim,Gary W. Miller,Takao Yagi,Akemi Matsuno-Yagi,J. Timothy Greenamyre +9 more
TL;DR: The involvement of oxidative damage in rotenone toxicity is demonstrated and antioxidant therapies for Parkinson's disease are supported, using three model systems of increasing complexity.
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Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation
TL;DR: It is demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular vein cannulation reproduced many features of Parkinson's disease in rats, including nigrostriatal dopaminergic degeneration and formation of alpha-synuclein-positive cytoplasmic inclusions in nigral neurons.
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An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage
Todd B. Sherer,Ranjita Betarbet,Amy K. Stout,Serena Lund,Melisa J. Baptista,Alexander Panov,Mark R. Cookson,J. Timothy Greenamyre +7 more
TL;DR: These studies indicate that chronic low-grade complex I inhibition caused by rotenone exposure induces accumulation and aggregation of α-synuclein and ubiquitin, progressive oxidative damage, and caspase-dependent death, mechanisms that may be central to PD pathogenesis.
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Animal models of Parkinson's disease
TL;DR: This review critically discusses animal models of Parkinson's disease and compares them with characteristics of the human disease.