Todd J. Suscovich

TL;DR: The functional ability of NK cells to differentially control HIV-1 replication in vitro based on their KIR and HLA types is examined, providing the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication.

TL;DR: In this article, an unbiased antibody profiling approach was used to show that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, such that Ltb infection is associated with unique Ab Fc functional profiles, selective binding to FcγRIII, and distinct Ab glycosylation patterns.

TL;DR: These studies demonstrate a sequential impairment ofNK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties.

TL;DR: It is demonstrated that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies, point to differences in disease trajectory, highlighting the potential importance of functional antigen- specific humoral immunity to guide patient care and vaccine development.

TL;DR: It is shown that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, which point to a potential role for Fc-mediated Ab effector functions, tuned via differential glycosylation, in Mtb control.