T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
Dicer1 functions as a haploinsufficient tumor suppressor
Madhu S. Kumar,Ryan E. Pester,Cindy Y. Chen,Keara Michelle Lane,Christine Chin,Jun Lu,David G. Kirsch,Todd R. Golub,Todd R. Golub,Todd R. Golub,Tyler Jacks +10 more
TL;DR: Dicer1 may be an important haploinsufficient tumor suppressor gene and, furthermore, that other factors controlling miRNA biogenesis may also function in this manner.
Journal ArticleDOI
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
Zejuan Li,Jun Lu,Jun Lu,Miao Sun,Shuangli Mi,Hao Zhang,Roger T. Luo,Ping Chen,Yungui Wang,Ming Yan,Zhijian Qian,Mary Beth Neilly,Jie Jin,Yanming Zhang,Stefan K. Bohlander,Dong-Er Zhang,Richard A. Larson,Michelle M. Le Beau,Michael J. Thirman,Todd R. Golub,Todd R. Golub,Todd R. Golub,Janet D. Rowley,Jianjun Chen +23 more
TL;DR: It is demonstrated that specific alterations in miRNA expression distinguish AMLs with common translocations and imply that the deregulation of specific miRNAs may play a role in the development of leukemia with these associated genetic rearrangements.
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A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.
Justin Lamb,Sridhar Ramaswamy,Sridhar Ramaswamy,Heide L. Ford,Bernardo Contreras,Robert V. Martinez,Frances S. Kittrell,Cynthia A. Zahnow,Nick Patterson,Todd R. Golub,Todd R. Golub,Mark E. Ewen +11 more
TL;DR: Patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene and this work demonstrates that tumor gene expression databases can be used to study the function of a humanoncogene in situ.
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An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
Alejandro Sweet-Cordero,Sayan Mukherjee,Sayan Mukherjee,Aravind Subramanian,Han You,Jeffrey J Roix,Christine Ladd-Acosta,Jill P. Mesirov,Todd R. Golub,Tyler Jacks +9 more
TL;DR: A method for comparing mouse models of cancer with human tumors using gene-expression profiling was applied to the analysis of a model of Kras2-mediated lung cancer and found a good relationship to human lung adenocarcinoma, thereby validating the model.
Journal ArticleDOI
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin,Itay Tirosh,Itay Tirosh,Volker Hovestadt,Volker Hovestadt,McKenzie Shaw,McKenzie Shaw,Leah E. Escalante,Leah E. Escalante,Nathan Mathewson,Cyril Neftel,Nelli Frank,Kristine Pelton,Christine M. Hebert,Christine M. Hebert,Christine Haberler,Keren Yizhak,Johannes Gojo,Kristof Egervari,Christopher Mount,Peter van Galen,Peter van Galen,Dennis M. Bonal,Quang-Dé Nguyen,Alexander M. Beck,Claire Sinai,Claire Sinai,Thomas Czech,Christian Dorfer,Liliana Goumnerova,Cinzia Lavarino,Angel M. Carcaboso,Jaume Mora,Ravindra Mylvaganam,Christina C. Luo,Andreas Peyrl,Mara Popović,Amedeo A. Azizi,Tracy T. Batchelor,Matthew P. Frosch,Maria Martinez-Lage,Mark W. Kieran,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Rameen Beroukhim,Rameen Beroukhim,Gerhard Fritsch,Gad Getz,Gad Getz,Orit Rozenblatt-Rosen,Kai W. Wucherpfennig,David N. Louis,Michelle Monje,Irene Slavc,Keith L. Ligon,Keith L. Ligon,Keith L. Ligon,Todd R. Golub,Todd R. Golub,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà +64 more
TL;DR: This study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.