T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Journal ArticleDOI
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.
Gregory V. Kryukov,Gregory V. Kryukov,Frederick H. Wilson,Frederick H. Wilson,Jason R. Ruth,Jason R. Ruth,Joshiawa Paulk,Joshiawa Paulk,Aviad Tsherniak,Sara Marlow,Sara Marlow,Francisca Vazquez,Francisca Vazquez,Barbara A. Weir,Barbara A. Weir,Mark E. Fitzgerald,Minoru Tanaka,Minoru Tanaka,Craig M. Bielski,Craig M. Bielski,Justin M. Scott,Courtney Dennis,Glenn S. Cowley,Jesse S. Boehm,David E. Root,Todd R. Golub,Clary B. Clish,James E. Bradner,James E. Bradner,William C. Hahn,William C. Hahn,Levi A. Garraway,Levi A. Garraway +32 more
TL;DR: The discovery of cancer dependencies has the potential to inform therapeutic strategies and to identify putative drug targets and reveal PRMT5 as a potential vulnerability across multiple cancer lineages augmented by a common “passenger” genomic alteration.
Journal ArticleDOI
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
Raajit K. Rampal,Raajit K. Rampal,Fatima Al-Shahrour,Omar Abdel-Wahab,Omar Abdel-Wahab,Jay P. Patel,Jean-Philippe Brunel,Craig H. Mermel,Craig H. Mermel,Adam J. Bass,Adam J. Bass,Jennifer Pretz,Jennifer Pretz,Jihae Ahn,Todd Hricik,Outi Kilpivaara,Martha Wadleigh,Lambert Busque,D. Gary Gilliland,Todd R. Golub,Todd R. Golub,Todd R. Golub,Benjamin L. Ebert,Benjamin L. Ebert,Ross L. Levine,Ross L. Levine +25 more
TL;DR: The data indicate that MPN patients, regardless of diagnosis or JAK2 mutational status, are characterized by a distinct gene expression signature with upregulation of JAK-STAT target genes, demonstrating the central importance of the Jak-STAT pathway in MPN pathogenesis.
Journal ArticleDOI
Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer
Sunita R. Setlur,Kirsten D. Mertz,Yujin Hoshida,Yujin Hoshida,Francesca Demichelis,Mathieu Lupien,Sven Perner,Sven Perner,Andrea Sboner,Yudi Pawitan,Ove Andrén,Laura A. Johnson,Jeff Tang,Hans-Olov Adami,Hans-Olov Adami,Stefano Calza,Stefano Calza,Arul M. Chinnaiyan,Daniel R. Rhodes,Scott A. Tomlins,Katja Fall,Lorelei A. Mucci,Philip W. Kantoff,Meir J. Stampfer,Swen Olof Andersson,Eberhard Varenhorst,Jan-Erik Johansson,Myles Brown,Todd R. Golub,Todd R. Golub,Mark A. Rubin +30 more
TL;DR: An 87-gene expression signature that distinguishes TMPRSS2-ERG fusion prostate cancer as a discrete molecular entity is identified and suggested that this fusion signature was associated with estrogen receptor (ER) signaling.
Journal ArticleDOI
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
T. W. Mclean,S. Ringold,Donna Neuberg,Kimberly Stegmaier,Ramana Tantravahi,Jerome Ritz,H. P. Koeffler,S. Takeuchi,J. W. G. Janssen,T. Seriu,C. R. Bartram,Stephen E. Sallan,D G Gilliland,Todd R. Golub +13 more
TL;DR: Co-immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together.
Journal ArticleDOI
MicroRNA miR-125a controls hematopoietic stem cell number
Shangqin Guo,Jun Lu,Rita Schlanger,Hao Zhang,Judy Y. Wang,Michelle Caroline Fox,Louise E. Purton,Heather H. Fleming,Bradley S. Cobb,Matthias Merkenschlager,Todd R. Golub,David T. Scadden +11 more
TL;DR: It is reported that the microRNA processing enzyme Dicer is essential for stem cell persistence in vivo and a specific microRNA, miR-125a, controls the size of the stem cell population by regulating hematopoietic stem/progenitor cell (HSPC) apoptosis.