T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Wesley C. Van Voorhis,John H. Adams,Roberto Adelfio,Vida Ahyong,Myles H. Akabas,Pietro Alano,Aintzane Alday,Alemán Resto Yesmalie,Aishah Alsibaee,Ainhoa Alzualde,Katherine T. Andrews,Simon V. Avery,Vicky M. Avery,Lawrence Ayong,Mark Baker,Stephen Baker,Choukri Ben Mamoun,Quentin D. Bickle,Lotfi Bounaadja,Tana Bowling,Jürgen Bosch,Lauren E. Boucher,Fabrice Fekam Boyom,José Brea,Marian P. Brennan,Audrey Burton,Conor R. Caffrey,Grazia Camarda,Manuela Carrasquilla,Dee A. Carter,Maria B. Cassera,Chih-Chien Cheng Ken,Worathad Chindaudomsate,Anthony J. Chubb,Beatrice L. Colon,Daisy D. Colón-López,Yolanda Corbett,Gregory J. Crowther,Noemi Cowan,Sarah D'Alessandro,Na Le Dang,Michael J. Delves,Joseph L. DeRisi,Alan Y. Du,Sandra Duffy,Shimaa Abd El-Salam El-Sayed,Michael T. Ferdig,José A. Fernández Robledo,David A. Fidock,Isabelle Florent,Patrick Valere Tsouh Fokou,Ani Galstian,Francisco-Javier Gamo,Suzanne Gokool,Ben Gold,Todd R. Golub,Gregory M. Goldgof,Rajarshi Guha,W. Armand Guiguemde,Nil Gural,R. Kiplin Guy,Michael Adsetts Edberg Hansen,Kirsten K. Hanson,Andrew Hemphill,Rob Hooft van Huijsduijnen,Takaaki Horii,Paul Horrocks,Tyler B. Hughes,Christopher D. Huston,Ikuo Igarashi,Katrin Ingram-Sieber,Maurice A. Itoe,Ajit Jadhav,Amornrat Naranuntarat Jensen,Laran T. Jensen,Rays H. Y. Jiang,Annette Kaiser,Jennifer Keiser,Thomas J. Ketas,Sébastien Kicka,Sunyoung Kim,Kiaran Kirk,Vidya Prasanna Kumar,Dennis E. Kyle,Maria Jose Lafuente,Scott M. Landfear,Nathan Lee,Sukjun Lee,Adele M. Lehane,Fengwu Li,David Little,Liqiong Liu,Manuel Llinás,María Isabel Loza,Aristea Lubar,Leonardo Lucantoni,Isabelle S Lucet,Louis Maes,Dalu Mancama,Nuha R. Mansour,Sandra March,Sheena McGowan,Iset Medina Vera,Stephan Meister,Luke Mercer,Jordi Mestres,Alvine Ngoutane Mfopa,Raj N. Misra,Seung-Hyun Moon,John P. Moore,Francielly Morais Rodrigues da Costa,Joachim Müller,Arantza Muriana,Stephen N. Hewitt,Bakela Nare,Carl Nathan,Nathalie Narraidoo,Sujeevi Nawaratna,Kayode K. Ojo,Diana Ortiz,Gordana Panic,George Papadatos,Silvia Parapini,Kailash P. Patra,Ngoc Minh Pham,Sarah Prats,David Plouffe,Sally-Ann Poulsen,Anupam Pradhan,Celia Quevedo,Ronald J. Quinn,Christopher A. Rice,Andrea Ruecker,Robert P. St.Onge,Rafaela Salgado Ferreira,Jasmeet Samra,Natalie G. Robinett,Ulrich Schlecht,Marjorie Schmitt,Filipe Silva Villela,Francesco Silvestrini,Robert E. Sinden,Dennis A. Smith,Thierry Soldati,Andreas Spitzmüller,Serge Maximilian Stamm,David J. Sullivan,William J. Sullivan,Sundari Suresh,Brian M. Suzuki,Yo Suzuki,S. Joshua Swamidass,Donatella Taramelli,Lauve R. Y. Tchokouaha,Anjo Theron,David Thomas,Kathryn F. Tonissen,Simon Townson,Abhai K. Tripathi,Valentin Trofimov,Kenneth O. Udenze,Imran Ullah,Cindy Vallières,Edgar Vigil,Joseph M. Vinetz,Phat Voong Vinh,Hoan Vu,Nao-aki Watanabe,Kate Weatherby,Pamela M. White,Andrew F. Wilks,Elizabeth A. Winzeler,Edward J. Wojcik,Melanie Wree,Wesley Wu,Naoaki Yokoyama,Paul Henri Amvam Zollo,Nada Abla,Benjamin Blasco,Jeremy N. Burrows,Benoît Laleu,Didier Leroy,Thomas Spangenberg,Timothy N. C. Wells,Paul Willis,Sangeeta N. Bhatia +185 more
TL;DR: The Medicines for Malaria Venture Malaria Box as mentioned in this paper is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite.
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Recurrent and functional regulatory mutations in breast cancer
Esther Rheinbay,Esther Rheinbay,Prasanna Parasuraman,Jonna Grimsby,Grace Tiao,Jesse M. Engreitz,Jesse M. Engreitz,Jaegil Kim,Michael S. Lawrence,Michael S. Lawrence,Amaro Taylor-Weiner,Sergio Rodríguez-Cuevas,Mara Rosenberg,Julian M. Hess,Chip Stewart,Yosef E. Maruvka,Yosef E. Maruvka,Petar Stojanov,Maria L. Cortes,Sara Seepo,Carrie Cibulskis,Adam Tracy,Trevor J. Pugh,Jesse Lee,Zongli Zheng,Leif W. Ellisen,A. John Iafrate,Jesse S. Boehm,Stacey Gabriel,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Jose Baselga,Alfredo Hidalgo-Miranda,Toshi Shioda,Andre Bernards,Eric S. Lander,Gad Getz +38 more
TL;DR: This study shows that promoter regions harbour recurrent mutations in cancer with functional consequences and that the mutations occur at similar frequencies as in coding regions.
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c-Myc is a critical target for c/EBPalpha in granulopoiesis.
Lisa M. Johansen,Atsushi Iwama,Tracey Lodie,Koichi Sasaki,Dean W. Felsher,Todd R. Golub,Daniel G. Tenen +6 more
TL;DR: It is shown that stable expression of c-Myc from an exogenous promoter not responsive to C/EBPα-mediated down-regulation forces myeloblasts to remain in an undifferentiated state, which is critical for allowing early myeloid precursors to enter a differentiation pathway.
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NFκB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes
Friedrich Feuerhake,Jeffery L. Kutok,Stefano Monti,Wen Chen,Ann S. LaCasce,Giorgio Cattoretti,Paul J. Kurtin,Geraldine S. Pinkus,Laurence de Leval,Nancy L. Harris,Kerry J. Savage,Donna Neuberg,Thomas M. Habermann,Riccardo Dalla-Favera,Todd R. Golub,Jon C. Aster,Margaret A. Shipp +16 more
TL;DR: In this large series ofPrimary mediastinal large B-cell lymphoma and DLBCLs, NFkappaB activation was not associated with amplification of the cREL locus, suggesting alternative pathogenetic mechanisms.
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Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.
Sandro Santagata,Marc L. Mendillo,Yun-Chi Tang,Yun-Chi Tang,Aravind Subramanian,Casey C. Perley,Stéphane P. Roche,Bang Wong,Rajiv Narayan,Hyoungtae Kwon,Martina Koeva,Angelika Amon,Angelika Amon,Todd R. Golub,John A. Porco,Luke Whitesell,Susan Lindquist +16 more
TL;DR: The ribosome functions as a central information hub in malignant cells: Translational flux conveys information about the cell’s metabolic status to regulate the transcriptional programs that support it, and multiple unbiased chemical and genetic approaches establish HSF1 as a prime transducer of this information.