T
Todd R. Golub
Researcher at Harvard University
Publications - 454
Citations - 234100
Todd R. Golub is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 164, co-authored 422 publications receiving 201457 citations. Previous affiliations of Todd R. Golub include Rush University Medical Center & Boston Children's Hospital.
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A resampling-based method for class discovery and visualization of gene expression microarray data
TL;DR: A new methodology of class discovery and clustering validation tailored to the task of analyzing gene expression data is presented and in conjunction with resampling techniques, it provides for a method to represent the consensus across multiple runs of a clustering algorithm and to assess the stability of the discovered clusters.
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Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Jing Wang,Hiromi Iwasaki,Andrei V. Krivtsov,Phillip G. Febbo,Aaron R. Thorner,Patricia Ernst,Erna Anastasiadou,Jeffery L. Kutok,Scott C. Kogan,Sandra S. Zinkel,Jill K. Fisher,Jay L. Hess,Todd R. Golub,Scott A. Armstrong,Koichi Akashi,Stanley J. Korsmeyer +15 more
TL;DR: This model of MLL‐CBP therapy‐related myeloproliferative disease demonstrates the selectivity of this MLL fusion for GMP cells and its ability to initiate leukemogenesis in conjunction with cooperating mutations.
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Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Susumu Kobayashi,Takeshi Shimamura,Stefano Monti,Ulrich Steidl,Christopher J. Hetherington,April M. Lowell,Todd R. Golub,Todd R. Golub,Todd R. Golub,Matthew Meyerson,Matthew Meyerson,Daniel G. Tenen,Geoffrey I. Shapiro,Balazs Halmos,Balazs Halmos +14 more
TL;DR: It is suggested that cyclin D1 may contribute to the emergence of EGFR-driven tumorigenesis and can be an alternative target of therapy in patients with advanced non-small cell lung cancer.
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A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
Mark-Anthony Bray,Sigrun M. Gustafsdottir,Mohammad Hossein Rohban,Shantanu Singh,Vebjorn Ljosa,Katherine L Sokolnicki,Joshua A. Bittker,Nicole E. Bodycombe,Vlado Dančík,Thomas P. Hasaka,Cindy S. Hon,Melissa M. Kemp,Kejie Li,Deepika Walpita,Mathias Wawer,Todd R. Golub,Stuart L. Schreiber,Paul A. Clemons,Alykhan F. Shamji,Anne E. Carpenter +19 more
TL;DR: This microscopy dataset includes 919 265 five-channel fields of view, representing 30 616 tested compounds, available at “The Cell Image Library” (CIL) repository, and includes data files containing morphological features derived from each cell in each image, both at the single-cell level and population-averaged level.
Journal Article
p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines.
TL;DR: It is suggested that the function of BCR can be largely replaced by the unrelated protein TEL with regards to transformation of murine hematopoietic cell lines to factor-independence, and support the hypothesis that a major contribution of both fusion partners is to activate the ABL tyrosine kinase.