Todd R. Golub

TL;DR: In this paper, a large-scale Bayes classification framework for across platform and multiple dataset classification is proposed. In one embodiment, the systems combine a Large Bayes classifier with a definition of combined relative features to represent the original values.

TL;DR: A transcriptomic signature of BMP4 signaling was predictive of an improved biologic response to the CDK4/6i palbociclib, in combination with an aromatase inhibitor in primary tumors.

TL;DR: In multiple human prostate expression data set, it was found that enrichment of glycolysis pathways in normal tissues was associated with decreased rates of cancer recurrence after prostatectomy, suggesting that parental strain expression mapping can directly identify germ-line modifier pathways of relevance to human disease.

TL;DR: The concept that acquired mutations in cancer may not contribute to malignant transformation is supported and the importance of functional validation of candidate alleles discovered using high-throughput genomic screens is underscored to distinguish between ‘driver’ mutations underlying cancer development, and biologically neutral ‘passenger’ alterations.

TL;DR: It is demonstrated that therapeutic inhibition of BAF complex has translational potential for children with H3K27M-gliomas, where genetic perturbation of the BAF catalytic subunit SMARCA4 (BRG1) opposes proliferation, promotes progression of differentiation along the astrocytic lineage, and improves overall survival of patient-derived xenograft models.