Todd R. Golub

TL;DR: In this paper, the authors show that global repression of miRNA maturation promotes cellular transformation and tumorigenesis in cancer cells expressing short hairpin RNAs (shRNAs) targeting three different components of the miRNA processing machinery.

TL;DR: The massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs indicates that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge.

TL;DR: It is found that mutation of BRAF is associated with enhanced and selective sensitivity to MEK inhibition when compared to either ‘wild-type’ cells or cells harbouring a RAS mutation, suggesting an exquisite dependency on MEK activity in BRAF mutant tumours.

TL;DR: CERES, a computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for the copy number–specific effect, is developed and found that CERES decreased false-positive results and estimated sgRNA activity for both this data set and previously published screens performed with different sg RNA libraries.

TL;DR: The JAK2V617F allele has been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF).