Todd R. Golub

TL;DR: ABBV-CLS-484 is a highly effective immunotherapy with monotherapy efficacy across mouse tumor models and small molecule inhibitors of PTPN2 offer a promising new strategy for cancer immunotherapy by targeting an IFN signaling checkpoint.

TL;DR: Concatenating original duplex for error correction (CODEC) as mentioned in this paper was proposed to detect biologically significant mutations from single DNA molecules using up to 100-fold fewer reads than duplex sequencing.

TL;DR: Significant regions of genomic gains and losses have been linked to expression and mutation data to find significant correlations at both single-gene and pathway levels and suggest that this integrative approach applied to a robust cancer cell line collection has considerable power to discover novel associations that augment ongoing basic research into cancer biology and drug discovery.

TL;DR: In this article , an intravenous DNA-binding priming agent given 2 hours prior to a blood draw was used to attenuate the clearance of cfDNA in vivo, which improved the sensitivity of existing DNA-based cancer testing using blood biopsies.