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Showing papers by "Tom J. Mabry published in 1998"


Journal ArticleDOI
TL;DR: The comprehensive quantitative analysis of the flavonoid chemistry of Artemisia vulgaris L., a plant used as an emmenagogue in traditional medicine, is presented in conjunction with an evaluation of its estrogenic activity.
Abstract: The comprehensive quantitative analysis of the flavonoid chemistry of Artemisia vulgaris L., a plant used as an emmenagogue in traditional medicine, is presented in conjunction with an evaluation of its estrogenic activity. Twenty known flavonoids were isolated and identified as tricine, jaceosidine, eupafolin, chrysoeriol, diosmetin, homoeriodictyol, isorhamnetin, apigenin, eriodictyol, luteolin, luteolin 7-glucoside, kaempferol 3-glucoside, kaempferol 7-glucoside, kaempferol 3-rhamnoside, kaempferol 3-rutinoside, quercetin 3-glucoside, quercetin 3-galactoside, quercetrin, rutin, and vitexin. The most abundant compounds were eriodictyol and luteolin. The estrogenic activity of all flavonoids was assayed by employing a reconstituted estrogen transcription unit in Saccharomyces cerevisiae transformed with both a human estrogen receptor expression plasmid and a reporter plasmid. Two flavonoids, eriodictyol and apigenin, were able to induce the transcription of the reporter gene in transgenic yeast. The transcriptional activity increased proportionally with increased amounts of purified eriodictyol or apigenin added to the yeast cells.

80 citations


Journal ArticleDOI
TL;DR: In this article, eight prenylated flavonoids, including three new compounds, have been isolated from chloroform extracts of stems and leaves of Maclura pomifera.

30 citations


Journal ArticleDOI
TL;DR: Re-investigation of the aerial parts of Iva frutescens resulted in the isolation of three sesquiterpenes, two of which are new natural products, and their structures were established by spectral data.

10 citations