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Showing papers by "Tom J. Mabry published in 2004"


Journal Article
TL;DR: The rat sera were collected and used to determine liver and kidney functions based on alanine amino transferase (ALT) and aspartate aminotransferase (AST) for both single and repeated administration, both materials proved to be non-toxic up to 2500 mg kg(-1) body weight.
Abstract: Two new flavonoids, takakin 7-O-glucoside (1) and bucegin 7-O-glucoside (2), and six other known compounds (3-8), takakin, isosctullarien, its 7-O-glucoside, takakin 8-O-glucoside, xanthotoxin and esculetin, were separated and identified from Glossostemon bruguieri. The new compounds were characterized using modern spectroscopic techniques, including UV spectroscopy, proton nuclear resonance ( 1 HNMR), carbon thirteen nuclear resonance ( 13 CNMR), homomolecular quantum coherance (HMQC), heteromolecular bonding connectivity (HMBC) and chemical ionization mass spectra (CI). The effect on rats urine volume of the plant powder, its ethanolic extract, (500 mg kg -1 ) along with four of the purified compounds (1,4-6), (100 mg kg -1 ) are described. Eight groups of albino rats (200-300 g body weight) (n=5 for each group) were used in the tests for a one-time treatment, and other seven groups (150-180 g body weight) (n=5 for each group) were tested using the same dose with repeated administration for 15 days. The rat sera were collected and used to determine liver and kidney functions based on alanine amino transferase (ALT) and aspartate amino transferase (AST) for both single and repeated administration. Levels of urea, creatinine and uric acid were determined for both sets of experiments. The toxic effects of both the powder and its alcoholic extract were also studied on mice to determine their LD50, both materials proved to be nontoxic up to 2500 mg kg -1 body weight.

12 citations


Journal ArticleDOI
TL;DR: In a study of Pacific Northwest plants of the Asteraceae family, a nor-ent-kaurane diterpene and a known diterPene, both displaying antibacterial activities, were isolated together with scopoletin and sitosterol-3-O-beta-glucopyranoside from the aerial parts of Antennaria geyeri.

11 citations