Author
Tom J. Mabry
Other affiliations: University of Illinois at Urbana–Champaign, Minia University, Dicle University ...read more
Bio: Tom J. Mabry is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Kaempferol & Sesquiterpene lactone. The author has an hindex of 42, co-authored 459 publications receiving 13375 citations. Previous affiliations of Tom J. Mabry include University of Illinois at Urbana–Champaign & Minia University.
Topics: Kaempferol, Sesquiterpene lactone, Germacranolide, Flavones, Hymenoxys
Papers published on a yearly basis
Papers
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TL;DR: The effect of 17-beta estradiol, genistein, daidzein and resveratrol on the activation status of signaling proteins that regulate cell survival and invasion, the cell properties underlying breast cancer progression is investigated.
Abstract: Flavonoids, such as daidzein and genistein, present in dietary plants like soybean, have unique chemical properties with biological activity relevant to cancer. Many flavonoids and polyphenols, including resveratrol in red wine and epigallocatechin gallate in green tea, are known antioxidants. Some of these compounds have estrogenic (and antiestrogenic) activity and are commonly referred to as phytoestrogens. A yeast-based estrogen receptor (ER) reporter assay has been used to measure the ability of flavonoids to bind to ER and activate estrogen responsive genes. Recently, estrogenic compounds were also shown to trigger rapid, nongenomic effects. The molecular mechanisms, however, have not been completely detailed and little information exists regarding their relevance to cancer progression. As a preliminary step toward elucidating rapid phytoestrogen action on breast cancer cells, we investigated the effect of 17-beta estradiol (E2), genistein, daidzein and resveratrol on the activation status of signaling proteins that regulate cell survival and invasion, the cell properties underlying breast cancer progression. The effect of these estrogenic compounds on the activation, via phosphorylation, of Akt/protein kinase B (Akt) and focal adhesion kinase (FAK) were analyzed in ER-positive and -negative human breast cancer cell lines. E2, genistein and daidzein increased whereas resveratrol decreased both Akt and FAK phosphorylation in nonmetastatic ER-positive T47D cells. In metastatic ER-negative MDA-MB-231 cells, all estrogenic compounds tested increased Akt and FAK phosphorylation. The inhibitory action of resveratrol on cell survival and proliferation is ER dependent. Therefore, all estrogenic compounds tested, including resveratrol, may exert supplementary ER-independent nongenomic effects on cell survival and migration in breast cancer cells.
126 citations
01 Jan 2007
TL;DR: In this article, the n-hexane extract of Syzygium aromaticum was extracted using gas chromatography-mass spectroscopy (GC-MS) and the major components were eugenol (71.56 %) and Eugenol acetate (8.99 %), along with limonin and ferulic aldehyde.
Abstract: Sixteen volatile compounds were identified from the n-hexane extract of the buds of Syzygium aromaticum by using gas chromatography-mass spectroscopy (GC-MS). The major components were eugenol (71.56 %) and eugenol acetate (8.99 %). The dichloromethane extract of the buds yielded limonin and ferulic aldehyde, along with eugenol. The flavonoids tamarixetin 3- O-b-D-glucopyranoside, ombuin 3-O-b-D-glucopyranoside and quercetin were isolated from the ethanol extract; identifications of all these compounds were established by chemical and spectroscopic methods including 1D and 2D NMR. This is the first report of limonin, ferulic aldehyde and these flavonoids from this plant. All extracts and the isolated flavonoids showed strong antioxidant activity against 1, 2-diphenyl picrylhydrazyl (DPPH). Among the tested extracts, the ethanol extract of the clove buds showed remarkable scavenging activity, as compared with synthetic antioxidants such as butylated hydroxyl toluene (BHT). The ethanol extract of clove showed remarkable hepatoprotective activity against paracetamol-induced liver injury in female rats.
113 citations
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TL;DR: Ten aglycones and six glycosides of luteolin and apigenin were identified from the leaves of Salvia palaestina Bentham (Labiatae) and cirsimaritin showed a high activity against Staphylococcus aureus and Escherichia coli.
Abstract: Ten aglycones and six glycosides of luteolin and apigenin were identified from the leaves of Salvia palaestina Bentham (Labiatae). Among them cirsimaritin showed a high activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa, while the others have little or no activity against the same bacterial strains.
112 citations
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TL;DR: In this paper, nine methylated flavonols isolated from Larrea cuneifolia Cav. collected in Argentina have been fully characterized using UV, MS and NMR spectral data, all of which were identified as methyl ethers of quercetin and kaempferol.
105 citations
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TL;DR: Among the classes of secondary compounds treated here, benzylisoquinoline alkaloids, iridoids and be–talains are shown to be the most important systematic markers used at present at higher levels of classification, although glucosinolates, polyacetylenes and some other types of alkaloid are also demonstrated to be valuable criteria for making taxonomic judgments above the family rank.
Abstract: The restricted distributions of some classes of secondary metabolites in the angiosperms make them valuable taxonomic characters in assessing systematic relationships at higher levels of classification. Yet, for several reasons, secondary metabolites have not, until recently, been widely used as taxonomic characters above the family level. In this paper, the distributions of a number of classes of secondary compounds are discussed with reference to four recently published systems of higher angiosperm classification: Cronquist's of 1981, Dahlgren's of 1980, Takhtajan's of 1980 and Thome's of 1981. Some of the problems faced in choosing and using secondary metabolite data for systematic purposes (including the effects of our increasing understanding of their functional significance) are covered as well. Among the classes of secondary compounds treated here, benzylisoquinoline alkaloids, iridoids and be–talains are shown to be the most important systematic markers used at present at higher levels of classification, although glucosinolates, polyacetylenes and some other types of alkaloids are also demonstrated to be valuable criteria for making taxonomic judgments above the family rank. In addition, certain terpenoids, flavonoids, phenolics, cyanogenic glycosides and non–protein amino acids are illustrated to be of systematic use in particular cases.
89 citations
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TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
8,513 citations
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TL;DR: A revised and updated classification for the families of the flowering plants is provided in this paper, which includes Austrobaileyales, Canellales, Gunnerales, Crossosomatales and Celastrales.
7,299 citations
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TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Abstract: Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.
4,663 citations
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TL;DR: In this article, two complementary colorimetric methods, aluminum chloride method and 2,4-dini trophenylhydrazine method, were used to determine the real content of total flavonoids in propolis.
3,899 citations
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TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.
3,630 citations