Author
Tom J. Mabry
Other affiliations: University of Illinois at Urbana–Champaign, Minia University, Dicle University ...read more
Bio: Tom J. Mabry is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Kaempferol & Sesquiterpene lactone. The author has an hindex of 42, co-authored 459 publications receiving 13375 citations. Previous affiliations of Tom J. Mabry include University of Illinois at Urbana–Champaign & Minia University.
Topics: Kaempferol, Sesquiterpene lactone, Germacranolide, Flavones, Hymenoxys
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lactones, including elamanolide and four new eudesmanolides.
13 citations
••
13 citations
••
TL;DR: Based on spectroscopic evidence, including a series of 2D-NMR analyses, the structure of the new triterpene is assigned as 24-des-isopropyl-7-ene-23-one-9,19; 16,24-dicycloart-3 beta,11 beta,16 alpha,24 alpha-tetraol 3-O-beta-D-xylopryanoside, named here as neocimiside
13 citations
••
TL;DR: Leaves and stems from endod (Phytolacca dodecandra L'Herit), known to produce the 29 kDa ribosome-inactivating protein (RIP) dodecandrin, were initiated into tissue culture and immuno-reactive proteins were detected in callus and in suspension cells.
Abstract: Leaves and stems from endod (Phytolacca dodecandra L'Herit), known to produce the 29 kDa ribosome-inactivating protein (RIP) dodecandrin, were initiated into tissue culture. Callus and suspension cultures were maintained on modified Murashige and Skoog medium plus 1.0 mg/l 2,4-dichlorophenoxyacetic acid. Six callus and two suspension cell lines were screened for dodecandrin production by western blots with affinitypurified antiserum. Antiribosomal activity of culture extracts was tested by in vitro translation assays. One suspension cell line was found to be free of immunoreactive proteins and a ribosome inhibitor. All other cell lines contain a ribosome inhibitor, although only two callus cell lines show detectable amounts of immunoreactive proteins at the same Mr as dodecandrin. Other immuno-reactive proteins were detected in callus (Mr 31000, 33000, 41000 and 43000) and in suspension cells (Mr 23000 and ∼43000), and may be ribosome inhibitors related to dodecandrin—either other RIPs or dodecandrin at various stages of processing.
13 citations
••
TL;DR: In this paper, Llave et al. used the ABTS+ [2,2′-azinobis(3-ethylbenzothiazolone-6-sulfonic acid)] free radical to scavenge quercetin and its 3-O.-rutinoside, ethyl acetate and ethanol extracts, and two new flavones from Casimiroa edulis.
Abstract: In the present current, quercetin and its 3-O.-rutinoside, the ethyl acetate and ethanol extracts, and two new flavones from Casimiroa edulis. Llave et Lex (Rotaceae) were tested for their antioxidant activity via scavenging by the ABTS˙+ [2,2′-azinobis(3-ethylbenzothiazolone-6-sulfonic acid)]free radical. Among all the tested fractions and compounds, the ethanol extract exhibited the strongest antioxidant activity followed by EtOAc extract, giving 842 and 712 µM Trolox equivalents/g dry weight, respectively. Moderate activities were detected for the other tested materials. The two new flavones were identified as 5-methoxy-6-hydroxyflavone and its 6-O.-β.-D-glucoside. The structure elucidation was based on UV, electrospray ionization mass spectrometry (ESIMS), 1H and 13C NMR, proton-proton correlation spectroscopy (1H-1H COSY), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC).
13 citations
Cited by
More filters
••
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
8,513 citations
••
TL;DR: A revised and updated classification for the families of the flowering plants is provided in this paper, which includes Austrobaileyales, Canellales, Gunnerales, Crossosomatales and Celastrales.
7,299 citations
•
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Abstract: Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.
4,663 citations
••
TL;DR: In this article, two complementary colorimetric methods, aluminum chloride method and 2,4-dini trophenylhydrazine method, were used to determine the real content of total flavonoids in propolis.
3,899 citations
••
TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.
3,630 citations