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Tom J. Mabry

Bio: Tom J. Mabry is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Kaempferol & Sesquiterpene lactone. The author has an hindex of 42, co-authored 459 publications receiving 13375 citations. Previous affiliations of Tom J. Mabry include University of Illinois at Urbana–Champaign & Minia University.


Papers
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Journal ArticleDOI
TL;DR: Achillea ligustica afforded two sesquiterpene lactones with rare 5/6/5 skeletons, three 1,10-seco-guaianolides and a chlorine-containing sesQUERPENE lactone as well as six known compounds, including two monoterpenes, two guaianolsides, one eudesmane and one secocaryophyllene derivative as mentioned in this paper.

49 citations

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TL;DR: A new aurone, 4,5-methylenedioxy-6-hydoxyaurone, isolated from chitin-treated liquid suspension cultures of Cephalocereus senilis showed antibacterial activity.

48 citations

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TL;DR: It is concluded that the aromatic ring of dopa is cleaved and that re-cyclization involving the nitrogen generates the dihydropyridine moiety.
Abstract: During studies on the biogenesis of betalains (I) in cactus fruits (Opuntia sp.). DL-dopa-1-[14C] and -2-[14C] were incorporated into betanin (III) which was obtained radiopure after crystallization. The specific activity remained constant after conversion to betanidin (IV) and to a neobetanidin derivative (IX). Reaction of radiobetanin with proline afforded indicaxanthin (V) carrying more than 90% of the radioactivity. Dopa (VI) is thus an efficient precursor for betalamic acid (VIII) but not for cyclodopa (VII). Decarboxylation of radiobetanidin and radioindicaxanthin showed that the carboxyl group of dopa remained a carboxyl group in the biotransformation to betalamic acid. It is concluded that the aromatic ring of dopa is cleaved and that re-cyclization involving the nitrogen generates the dihydropyridine moiety. Under the same conditions mevalonic acid, aspartic acid and phenylalanine showed low incorporations. Studies with beet seedlings and DL-dopa-1-[14C], -2-[14C] and DL-tyrosine-1-[14C] afforded similar results but with low incorporations.

46 citations

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TL;DR: The data suggest that plants in the Lemnaceae O-substitute flavones but do not C-glycosylate them, and evidence was obtained that flavones containing a 4′-monohydroxy B-ring can be oxidized to flavones with a 3′,4′-dihydroxy A-ring.

44 citations

Journal ArticleDOI
TL;DR: In this article, it was shown that the van der Waal's proximity effect of the C8-α-hydroxyl group on sesquiterpene lactones can be used for making certain stereochemical and conformational assignments.

44 citations


Cited by
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Journal ArticleDOI
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.

8,513 citations

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TL;DR: A revised and updated classification for the families of the flowering plants is provided in this paper, which includes Austrobaileyales, Canellales, Gunnerales, Crossosomatales and Celastrales.

7,299 citations

Journal Article
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Abstract: Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, and red wine. They are low molecular weight compounds composed of a three-ring structure with various substitutions. This basic structure is shared by tocopherols (vitamin E). Flavonoids can be subdivided according to the presence of an oxy group at position 4, a double bond between carbon atoms 2 and 3, or a hydroxyl group in position 3 of the C (middle) ring. These characteristics appear to also be required for best activity, especially antioxidant and antiproliferative, in the systems studied. The particular hydroxylation pattern of the B ring of the flavonoles increases their activities, especially in inhibition of mast cell secretion. Certain plants and spices containing flavonoids have been used for thousands of years in traditional Eastern medicine. In spite of the voluminous literature available, however, Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional. Suggestions are made where such possibilities may be worth pursuing.

4,663 citations

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TL;DR: In this article, two complementary colorimetric methods, aluminum chloride method and 2,4-dini trophenylhydrazine method, were used to determine the real content of total flavonoids in propolis.

3,899 citations

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TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.

3,630 citations