T
Tom Van de Wiele
Researcher at Ghent University
Publications - 253
Citations - 9906
Tom Van de Wiele is an academic researcher from Ghent University. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 47, co-authored 227 publications receiving 7743 citations.
Papers
More filters
Journal ArticleDOI
Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity
Annelies Geirnaert,Annelies Geirnaert,Marta Calatayud,Charlotte Grootaert,Debby Laukens,Sarah Devriese,Guy Smagghe,Martine De Vos,Nico Boon,Tom Van de Wiele +9 more
TL;DR: Proof-of-concept data for the therapeutic potential of butyrate-producing bacteria in CD is provided and the future preclinical development of a probiotic product containing butyrATE-producing species is supported.
Journal ArticleDOI
The Prenylflavonoid Isoxanthohumol from Hops (Humulus lupulus L.) Is Activated into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in the Human Intestine
Sam Possemiers,Selin Bolca,Charlotte Grootaert,Arne Heyerick,Karel Decroos,Willem Dhooge,Denis De Keukeleire,Sylvie Rabot,Willy Verstraete,Tom Van de Wiele +9 more
TL;DR: Data show that intestinal conversion of IX upon moderate beer consumption can lead to 8-PN exposure values that might fall within the range of human biological activity.
Journal ArticleDOI
Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene.
Hans Verstraelen,Ramiro Vilchez-Vargas,Fabian Desimpel,Ruy Jauregui,Nele Vankeirsbilck,Steven Weyers,Rita Verhelst,Petra De Sutter,Dietmar H. Pieper,Tom Van de Wiele +9 more
TL;DR: The findings are consistent with the presence of a unique microbiota dominated by Bacteroides residing on the endometrium of the human non-pregnant uterus and likely to have a previously unrecognized role in uterine physiology and human reproduction.
Journal ArticleDOI
Structurally Different Wheat-Derived Arabinoxylooligosaccharides Have Different Prebiotic and Fermentation Properties in Rats
Valerie Van Craeyveld,Katrien Swennen,Emmie Dornez,Tom Van de Wiele,Massimo Marzorati,Willy Verstraete,Yasmine Delaedt,Okanlawon Onagbesan,Eddy Decuypere,Johan Buyse,Bart De Ketelaere,Willem F. Broekaert,Jan A. Delcour,Christophe M. Courtin +13 more
TL;DR: New insights into the structure-activity relation ofAXOS open up new perspectives for the production and application of AXOS preparations with optimized prebiotic and fermentation properties.
Journal ArticleDOI
Human Colon Microbiota Transform Polycyclic Aromatic Hydrocarbons to Estrogenic Metabolites
Tom Van de Wiele,Lynn Vanhaecke,Charlotte Boeckaert,Kerry M. Peru,John V. Headley,Willy Verstraete,Steven D. Siciliano +6 more
TL;DR: The results imply that the PAH bioactivation potency of colon microbiota is not eliminated by the presence of soil, and suggests that current risk assessment may underestimate the risk from ingested PAHs.