T
Tomáš Hanke
Researcher at University of Oxford
Publications - 199
Citations - 9117
Tomáš Hanke is an academic researcher from University of Oxford. The author has contributed to research in topics: Vaccinia & Immunogenicity. The author has an hindex of 50, co-authored 190 publications receiving 8582 citations. Previous affiliations of Tomáš Hanke include Kumamoto University & McMaster University.
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Journal ArticleDOI
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
Jörg Schneider,Sarah C. Gilbert,Tom Blanchard,Tomáš Hanke,Kathryn J. H. Robson,Carolyn M. Hannan,Marion Becker,Robert E. Sinden,Geoffrey L. Smith,Adrian V. S. Hill,Adrian V. S. Hill +10 more
TL;DR: DNA priming followed by MVA boosting may provide a general immunization regime for induction of high levels of CD8+ T cells and was abrogated when the order of immunization was reversed.
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Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen
Tomáš Hanke,Rachel V. Samuel,Tom Blanchard,Veronica C. Neumann,Todd M. Allen,Jon E. Boyson,Sally A. Sharpe,Nicola Cook,Geoffrey L. Smith,David I. Watkins,Martin Cranage,Andrew J. McMichael +11 more
TL;DR: It is demonstrated clearly that the DNA prime-MVA boost regimen is an effective protocol for induction of CTLs in macaques, and the correlations of tetramer staining of peripheral blood lymphocytes with CTL killing in vitro and postchallenge control of viremia are discussed.
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Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen
Todd M. Allen,Thorsten U. Vogel,Deborah H. Fuller,Bianca R. Mothé,Susan R. Steffen,Jon E. Boyson,Tim Shipley,James T. Fuller,Tomáš Hanke,Alessandro Sette,John D. Altman,Bernard Moss,Andrew J. McMichael,David I. Watkins +13 more
TL;DR: An epitope-based DNA prime/modified vaccinia virus Ankara (MVA) boost vaccine to induce CTL responses against a single SIVgag CTL epitope represents a potent method for inducing high levels of functionally active, Ag-specific CD8+ T lymphocytes in non-human primates.
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Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
Sven Létourneau,Eung-Jun Im,Tumelo Mashishi,Choechoe Brereton,Anne Bridgeman,Hongbing Yang,Lucy Dorrell,Tao Dong,Bette T. Korber,Bette T. Korber,Andrew J. McMichael,Tomáš Hanke +11 more
TL;DR: This vaccine approach provides an attractive and testable alternative for overcoming the HIV-1 variability, while focusing T cell responses on regions of the virus that are less likely to mutate and escape, and has merit in the simplicity of design and delivery.
Journal ArticleDOI
HIV vaccines 1983-2003.
Andrew J. McMichael,Tomáš Hanke +1 more
TL;DR: More than 20 HIV vaccines designed to stimulate T-cell responses are being developed, and it is unclear whether any of them will work.