Tomasz Burzykowski

TL;DR: Novel stemness indices for assessing the degree of oncogenic dedifferentiation are provided and it is found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors.

TL;DR: Among the RCTs included, postoperative adjuvant chemotherapy based on fluorouracil regimens was associated with reduced risk of death in gastric cancer compared with surgery alone.

TL;DR: In this article, the authors proposed a new method for the validation of surrogate endpoints, which leads to the prediction of the effect of treatment upon the true endpoint, given its observed effect upon the surrogate endpoint.

TL;DR: Analysis of individual data from 3791 patients enrolled in 25 randomised trials of first-line treatment with standard bolus intravenous fluoropyrimidines versus experimental treatments confirms that an increase in tumour response rate translates into a increase in overall survival for patients with advanced colorectal cancer.