Author
Tomihisa Ohta
Other affiliations: Hokkaido University, Kanazawa University
Bio: Tomihisa Ohta is an academic researcher from Tohoku University. The author has contributed to research in topics: Amino acid & Absolute configuration. The author has an hindex of 21, co-authored 52 publications receiving 1288 citations. Previous affiliations of Tomihisa Ohta include Hokkaido University & Kanazawa University.
Papers published on a yearly basis
Papers
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TL;DR: A pentacyclic aromatic alkaloid, ascididemin (1), with potent antineoplastic activity has been isolated from the Okinawan tunicate Didemnum sp..
129 citations
TL;DR: In this article, three bromopyrrole alkaloids, ageliferin (1), bromoageliferins (2), and dibromo-agelifierin (3), have been isolated as potent actomyosin ATPase activators from the Okinawan marine sponge Agelas sp.
104 citations
TL;DR: In this paper, a new polyoxygenated xanthone mangostanol was isolated from the fruit hull of Garcinia mangostana, along with known xanthones, α-mangostin, γ-mengostin and gartanin, 8-deoxygartnin, 5,9-dihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H,6 H -pyrano[3, 2-b ]xanthen
85 citations
TL;DR: In the isolated rabbit thoracic aorta and guinea-pig trachea, alpha-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of cimetidine, a histamine H2 receptor antagonist as discussed by the authors.
76 citations
TL;DR: In this paper, pyridine alkaloids, theonelladins A ∼ D, with potent antileukemic activity have been isolated from the Okinawan marine sponge Theonella swinhoei and the structures elucidated on the basis of spectroscopic data.
74 citations
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TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
TL;DR: Flavonoids are plant pigments that are synthesised from phenylalanine, generally display marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are excited by UV light, and are ubiquitous to green plant cells.
2,424 citations
Patent•
TL;DR: In this paper, the present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesyation of the oncogene protein Ras.
Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras
892 citations
TL;DR: This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of human CYP enzymes published previously by Rendic and DiCarlo, now covering selection of the literature through 2001 in the reference section.
Abstract: This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of human CYP enzymes published previously by Rendic and DiCarlo (1), now covering selection of the literature through 2001 in the reference section. The data are presented in a tabular form (Table 1) to provide a framework for predicting and interpreting the new P450 metabolic data. The data are formatted in an Excel format as most suitable for off-line searching and management of the Web-database. The data are presented as stated by the author(s) and in the case when several references are cited the data are presented according to the latest published information. The searchable database is available either as an Excel file (for information contact the author), or as a Web-searchable database (Human P450 Metabolism Database, www.gentest.com) enabling the readers easy and quick approach to the latest updates on human CYP metabolic reactions.
788 citations
694 citations