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Tommi Kekki

Bio: Tommi Kekki is an academic researcher from VTT Technical Research Centre of Finland. The author has contributed to research in topics: Groundwater & Anoxic waters. The author has an hindex of 6, co-authored 21 publications receiving 129 citations.

Papers
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Journal ArticleDOI
TL;DR: It was concluded that the in vivo mucoadhesion of MCCh formulations is erratic, and that the formulations studied are not reliable gastro-retentive drug delivery systems.

38 citations

Journal ArticleDOI
TL;DR: In a hypothetical severe accident in a nuclear power plant, molten materials may come into contact with concrete, causing concrete ablation in five HECLA experiments the interaction between metallic melt and concrete was investigated by pouring molten stainless steel at almost 1800°C into cylindrical concrete crucibles The tests were transient, ie no decay heat simulation was used as mentioned in this paper.

30 citations

Journal ArticleDOI
TL;DR: This paper is a report from a pharmacoscintigraphic study with an Egalet constant-release system containing caffeine and natural abundance samarium oxide, which found that a long residence time in the ascending and transverse colon led to high AUC values for caffeine.

20 citations

Journal ArticleDOI
TL;DR: The faster disintegration of the HPMC K100-based capsules explains the differences in the pharmacokinetic profiles of the model drugs between the H PMC K 100- and K4M- based capsules in previous studies.

19 citations

01 Jan 2014
TL;DR: In this paper, a literature survey was conducted to collect information on: i) the chemical behaviour of irradiated aluminium and graphite in decommissioning waste under expected final repository conditions.
Abstract: The Finnish FiR 1 TRIGA Mark II reactor is facing shut-down after more than 50 years of operation. The decommissioning of the reactor is planned to start during fall 2015. The management and final disposal of the decommissioning waste require knowledge about, among other things, the possible waste-related chemical reactions and the effects of such reactions on long-term safety. The above warrants the rationale for the literature survey, which was conducted to collect information on: i) The chemical behaviour of irradiated aluminium and graphite in FiR 1 decommissioning waste under expected final repository conditions. ii) The international practices concerning the management and final disposal of irradiated aluminium and graphite. iii) The experimental techniques for determining the chemical form (organic or inorganic) of the C released from graphite waste. The report describes initially the FiR 1 TRIGA reactor, its associated decommissioning waste and foreseen final disposal conditions. The main part of the report focuses on the chemical behaviour of aluminium and graphite under such conditions. In addition, a few examples are provided concerning available methods for managing irradiated graphitic waste and for measuring the contents of organic and inorganic C in irradiated graphite. Finally, the report proposes outlines for some experiments to be conducted at VTT in order to determine the release rates of organic and inorganic C from the FiR 1 decommissioning waste.

8 citations


Cited by
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Journal ArticleDOI
TL;DR: The success and degree of muco-adhesive bonding is influenced by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional groupings as mentioned in this paper.

720 citations

Journal ArticleDOI
TL;DR: The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.
Abstract: Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug accumulation. To explain the mechanisms for enhancement of oral bioavailability, we discussed the special stability of PMs, the controlled release properties of pH-sensitive PMs, the prolongation of residence time with mucoadhesive PMs, and the P-gp inhibitors commonly used in PMs, respectively. The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.

424 citations

Journal ArticleDOI
TL;DR: This work has summarized the important physiologic parameters, which act upon the gastric residence time, and focused on gastroretentive dosage forms especially designed against H. pylori, including specific targeting systems against this bacterium.

389 citations

Journal ArticleDOI
TL;DR: Approaches to achieving prolonged residence times of the devices in the upper part of the gastrointestinal tract include the use of bioadhesive, size-increasing, and floating drug delivery systems.

289 citations

Journal ArticleDOI
TL;DR: Methods to increase the residence of drug formulations at or above the absorption window are discussed in this review, including bioadhesive microspheres that have a slow intestinal transit and the gastroretentive dosage system, which is based on multiparticulates or large single unit systems.

269 citations