Author
Tomoco I. Kusumoto
Bio: Tomoco I. Kusumoto is an academic researcher. The author has contributed to research in topics: Helicteres isora. The author has an hindex of 2, co-authored 3 publications receiving 44 citations.
Topics: Helicteres isora
Papers
More filters
TL;DR: In this article, the authors examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines, and isolated three new neolignans, helisterculins A (1 and B (2) and helisorin (3), and elucidated their structures by spectral analyses.
Abstract: During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a water extract of the fruits, we isolated three new neolignans, helisterculins A (1) and B (2) and helisorin (3), and elucidated their structures by spectral analyses. Helisterculins A (1) and B (2) are (7.5′,8.2′)-neolignans with a bicyclo[2.2.2]octene C-framework, while helisorin (3) is a (6.4′,7.5′,8.2′)-neolignan with a very rare 4,4a,9,9a-tetrahydro-3,9-methano-3H-fluorene C-framework. The natural product with the latter C-framework has no literature precedent. The neolignans 1 – 3 showed weak inhibitory activity against reverse transcriptase from avian myeloblastosis virus.
27 citations
TL;DR: In this paper, the authors examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines, and isolated six new neolignans, the helicterins A, − F (1 -6), and elucidated their structures by spectral analyses.
Abstract: During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a H2O extract of the fruits, we isolated six new neolignans, the helicterins A – F (1 – 6), and elucidated their structures by spectral analyses. Helicterins A – F (1 – 6) are dimeric (7.5′,8.2′)-neolignans with a bicyclo[2.2.2]octene C-framework, and showed mild inhibitory activity against reverse transcriptase from avian myeloblastosis virus.
16 citations
TL;DR: In this paper, the authors examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines, and isolated six new neolignans, the helicterins A, − F (1 -6), and elucidated their structures by spectral analyses.
Abstract: During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a H2O extract of the fruits, we isolated six new neolignans, the helicterins A – F (1 – 6), and elucidated their structures by spectral analyses. Helicterins A – F (1 – 6) are dimeric (7.5′,8.2′)-neolignans with a bicyclo[2.2.2]octene C-framework, and showed mild inhibitory activity against reverse transcriptase from avian myeloblastosis virus.
1 citations
Cited by
More filters
TL;DR: This paper surveyed the most frequently used plants in jamu that have also been investigated regarding their constituents and pharmacological effects and gave comprehensive views that can be used in its future development for the further improvement of its utility in curing illnesses and maintaining good health.
233 citations
TL;DR: A review of natural Diels-Alder type cycloadducts, synthetic efforts on the chemical feasibility of the biosynthetic diels-alder reaction and a brief history of studies on Diels−alderases are discussed in this article.
207 citations
TL;DR: A floristic survey of ethnomedicinal plants occurring in the tribal area of Rajasthan was conducted to assess the potentiality of plant resources for modern treatments and information on medicinal uses of plants is based on the exhaustive interviews with local physicians practising indigenous system of medicine, village headmen, priests and tribal folks.
188 citations
127 citations
TL;DR: The ethanol, ethyl acetate and butanol extracts of Helicteres isora root showed significant oral hypoglycemic activity on glucose loaded rats at a dose of 250 mg/kg.
117 citations