T
Tomohiro Kawaguchi
Researcher at Tokyo Medical University
Publications - 5
Citations - 217
Tomohiro Kawaguchi is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Endoplasmic reticulum & Autophagy. The author has an hindex of 4, co-authored 5 publications receiving 198 citations.
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Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: Crosstalk among proteasome, autophagy-lysosome and ER stress
Tomohiro Kawaguchi,Keisuke Miyazawa,Shota Moriya,Tadashi Ohtomo,Xiao-Fang Che,Munekazu Naito,Masahiro Itoh,Akio Tomoda +7 more
TL;DR: Combined treatment with BZ and bafilomycin A1 (BAF), which is a specific inhibitor of vacuolar-ATPase and is used as an autophagy inhibitor at the late stage, resulted in synergistic cytotoxicity, compared with that by either BZ or BAF alone.
Journal ArticleDOI
Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells
Shota Moriya,Xiao-Fang Che,Seiichiro Komatsu,Akihisa Abe,Tomohiro Kawaguchi,Akihiko Gotoh,Masato Inazu,Akio Tomoda,Keisuke Miyazawa +8 more
TL;DR: Simultaneously targeting two major intracellular protein degradation systems such as the ubiquitin-proteasome system by BZ and the autophagy-lysosomes system by a macrolide antibiotic enhances ER stress-mediated apoptosis in MM cells.
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Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells
TL;DR: Comparison of expression profiles of endoplasmic reticulum stress-related genes in U266 multiple myeloma cells after treatment with Phx-3 and the ER stress inducers tunicamycin (TNM) and thapsigargin (TPG) indicated that ER stress-mediated CHOP induction by PhX-3 is involved in the cytotoxic effect.
Journal ArticleDOI
Macrolide Antibiotics Block Autophagy Flux and Sensitize to Bortezomib Via Endoplasmic Reticulum-Stress-Mediated CHOP Induction in Myeloma Cells
Shota Moriya,Xiao-Fang Che,Seiichiro Komatsu,Akihisa Abe,Tomohiro Kawaguchi,Akihiko Gotoh,Masato Inazu,Akio Tomoda,Keisuke Miyazawa +8 more
TL;DR: This work investigated whether simultaneous inhibition of protein degradation systems such as the ubiquitin-proteasome system by BZ and the autophagy-lysosomes system by a macrolide antibiotic enhances ER-stress-mediated apoptosis in MM cells.
Journal ArticleDOI
Combined Treatment with Bortezomib Plus Bafilomycin A1 Enhances Cytocidal Effect along with Induction of ER Stress In Myeloma Cells: Crosstalk Among Proteasome, Autophagy-Lysosome, and ER Stress
Keisuke Miyazawa,Shota Moriya,Tomohiro Kawaguchi,Tadashi Ohtomo,Xiao-Fang Che,Munekazu Naito,Masahiro Itoh,Akio Tomoda +7 more
TL;DR: The data suggest that ER stress, but not inhibition of NF-kB, is involved in BZ-induced cytotoxicity in MM cells, and also suggest the tight linkage among autophagy, proteasome, and ER stress.