T
Tomohito Yagi
Researcher at Kyoto Prefectural University of Medicine
Publications - 27
Citations - 936
Tomohito Yagi is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Single-nucleotide polymorphism & Genotype. The author has an hindex of 13, co-authored 27 publications receiving 881 citations. Previous affiliations of Tomohito Yagi include SANTEN PHARMACEUTICAL CO., LTD..
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Journal ArticleDOI
Identification of a gene expression signature associated with pediatric AML prognosis
Tomohito Yagi,Akira Morimoto,Mariko Eguchi,Shigeyoshi Hibi,Masahiro Sako,Eiichi Ishii,Shuki Mizutani,Shinsaku Imashuku,Misao Ohki,Hitoshi Ichikawa +9 more
TL;DR: The results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.
Journal ArticleDOI
Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population
Masakazu Nakano,Yoko Ikeda,Takazumi Taniguchi,Tomohito Yagi,Masahiro Fuwa,Natsue Omi,Yuichi Tokuda,Masami Tanaka,Kengo Yoshii,Masaaki Kageyama,Shigeta Naruse,Akira Matsuda,Kazuhiko Mori,Shigeru Kinoshita,Kei Tashiro +14 more
TL;DR: It turned out that 3 genetic loci probably associated with POAG have been identified, and these findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis.
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Characteristic perforin gene mutations of haemophagocytic lymphohistiocytosis patients in Japan.
Ikuyo Ueda,Akira Morimoto,Tohru Inaba,Tomohito Yagi,Shigeyoshi Hibi,Tohru Sugimoto,Masahiro Sako,Fumio Yanai,Takashi Fukushima,Masahiko Nakayama,Eiichi Ishii,Shinsaku Imashuku +11 more
TL;DR: Examination of the geographical origins of the ancestors in the perforin‐mutant HLH patients revealed that they mostly came from the Western part of Japan, suggesting that the present‐day cases may largely derive from a common ancestor.
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High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis
Tomohito Yagi,Shigeyoshi Hibi,Mami Takanashi,Gen Kano,Yasuhiro Tabata,Toshihiko Imamura,Tohru Inaba,Akira Morimoto,Shinjiro Todo,Shinsaku Imashuku +9 more
TL;DR: The pathogenesis of myelomonocytic/monocytic AML may involve aberrant regulation of apoptosis due to unscheduled expression of the Ik6 isoform, which may inhibit the normal transcriptional regulation of hematopoietic cell development.
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Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia.
Tomohito Yagi,Shigeyoshi Hibi,Yasuhiro Tabata,Kikuko Kuriyama,Tomoko Teramura,Tetsuo Hashida,Yoshitaka Shimizu,Tetsuya Takimoto,Shinjiro Todo,Tadashi Sawada,Shinsaku Imashuku +10 more
TL;DR: The findings strongly suggest a prenatal origin for some cases of B-cell precursor ALL lacking specific clonotypic abnormalities, which are supported by studies of identical infant twins with concordant leukemia and of nontwined patients with MLL gene rearrangements.