Author
Tomoko Mori
Bio: Tomoko Mori is an academic researcher from Nagasaki University. The author has contributed to research in topics: Bicyclic molecule & Quinoline. The author has an hindex of 1, co-authored 1 publications receiving 31 citations.
Topics: Bicyclic molecule, Quinoline, Isoquinoline, Pyridinium, Indolizine
Papers
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TL;DR: The reaction of pyridinium or isoquinolinium N-ylides with methoxy-substituted ethylenes gave the corresponding indolizine and pyrrolo[2,1-a]isoquinoline derivatives bearing acetyl, aroyl, cyano, ester group at the 1-position in one step as mentioned in this paper.
32 citations
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TL;DR: Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor and a Ki value of 2.0 nM was observed.
90 citations
TL;DR: Rhodium(III)-catalyzed oxidative annulation reactions of pyridinium trifluoromethanesulfonate salts with alkynes leading to substituted indolizines by cleavage of C(sp(2)-H/C(3))-H bonds are developed and provide a new efficient route to indolIZine derivatives.
59 citations
TL;DR: The indolizine core can be constructed from a pyridine, two aldehydes, and a nitroalkane, and no undesired functional groups remain in the products as discussed by the authors.
59 citations
TL;DR: The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides.
Abstract: The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides. This methodology is distinguished by the use of a commercially inexpensive catalyst and readily available starting materials, wide substrate scope, and operational simplicity.
55 citations
TL;DR: In this paper, a facile and general one-step method is presented for the synthesis of aromatic indolizine compounds 3a-n in moderate to high yields (53-99%) by reaction of the pyridinium N-ylides 1a, e, f, g, and isoquinolinium Nylide 1g with various olefinic dipolarophiles, such as acrylonitrile 2a, methyl acrylate 2b, acrylamide 2c, diethyl maleate 2d and methyl croton
Abstract: A facile and general one-step method is presented for the synthesis of aromatic indolizine compounds 3a–n in moderate to high yields (53–99%) by reaction of the pyridinium N-ylides 1a–e, the quinolinium N-ylide 1f and the isoquinolinium N-ylide 1g with various olefinic dipolarophiles, such as acrylonitrile 2a, methyl acrylate 2b, acrylamide 2c, diethyl maleate 2d and methyl crotonate 2e, respectively, in the presence of a new oxidant TPCD [Copy4(HCrO4)2, tetrapyridinecobalt(II) dichromate] at 90 °C for 2 h in DMF.
49 citations