T
Tomomi Ide
Researcher at Kyushu University
Publications - 205
Citations - 8824
Tomomi Ide is an academic researcher from Kyushu University. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 44, co-authored 171 publications receiving 7318 citations. Previous affiliations of Tomomi Ide include Kumamoto University & University of Pennsylvania.
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Journal ArticleDOI
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Hideo Utsumi,Dongchon Kang,Nobutaka Hattori,Koji Uchida,Ken ichi Arimura,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: Direct evidence is provided for the involvement of ROS in the mitochondrial origin of HF myocytes, which might be responsible for both contractile dysfunction and structural damage to the myocardium.
Journal ArticleDOI
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction.
Tomomi Ide,Hiroyuki Tsutsui,Shunji Hayashidani,Dongchon Kang,Nobuhiro Suematsu,Kei-ichiro Nakamura,Hideo Utsumi,Naotaka Hamasaki,Akira Takeshita +8 more
TL;DR: It is hypothesized that ROS may induce mitochondrial DNA (mtDNA) damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes and thus may contribute to the progression of left ventricular remodeling and failure after myocardial infarction.
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Direct Evidence for Increased Hydroxyl Radicals Originating From Superoxide in the Failing Myocardium
Tomomi Ide,Hiroyuki Tsutsui,Shintaro Kinugawa,Nobuhiro Suematsu,Shunji Hayashidani,Kazuhiro Ichikawa,Hideo Utsumi,Youji Machida,Kensuke Egashira,Akira Takeshita +9 more
TL;DR: There was a significant positive relation between myocardial ROS level and left ventricular contractile dysfunction and, in the failing myocardium, *OH was produced as a reactive product of *O(2)(-) and H(2)O( 2), which might play an important role inleft ventricular failure.
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Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice Role of Oxidative Stress
Shintaro Kinugawa,Hiroyuki Tsutsui,Shunji Hayashidani,Tomomi Ide,Nobuhiro Suematsu,Shinji Satoh,Hideo Utsumi,Akira Takeshita +7 more
TL;DR: The attenuation of increased myocardial ROS and metalloproteinase activity with DMTU may contribute, at least in part, to its beneficial effects on LV remodeling and failure.
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Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the ligation of PPARγ
L. Chastine Bell-Parikh,Tomomi Ide,John A. Lawson,Peter McNamara,Muredach P. Reilly,Garret A. FitzGerald +5 more
TL;DR: In this paper, the 15-deoxy-Delta12,14-PGJ2 (15d)-Ligand was identified as an endogenous ligand for PPARgamma, inducing adipogenesis in vitro.