T
Tomonori Sumida
Researcher at Hiroshima University
Publications - 18
Citations - 540
Tomonori Sumida is an academic researcher from Hiroshima University. The author has contributed to research in topics: Carcinoma & Metastasis. The author has an hindex of 7, co-authored 18 publications receiving 505 citations.
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Journal ArticleDOI
Mesenchymal stem cells enhance growth and metastasis of colon cancer.
Kei Shinagawa,Yasuhiko Kitadai,Miwako Tanaka,Tomonori Sumida,Michiyo Kodama,Yukihito Higashi,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +8 more
TL;DR: Collectively, MSCs migrate and differentiate into CAFs in tumor stroma, and they promote growth and metastasis of colon cancer by enhancing angiogenesis, migration and invasion and by inhibiting apoptosis of tumor cells.
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Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinoma.
Michiyo Kodama,Yasuhiko Kitadai,Tomonori Sumida,Mayu Ohnishi,Eiji Ohara,Miwako Tanaka,Kei Shinagawa,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +9 more
TL;DR: The data indicate that secretion of PDGF‐B by gastric carcinoma cells and expression ofPDGF‐Rβ by tumor‐associated stromal cells are associated with lymphatic metastasis.
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Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer
Kei Shinagawa,Yasuhiko Kitadai,Miwako Tanaka,Tomonori Sumida,Mieko Onoyama,Mayu Ohnishi,Eiji Ohara,Yukihito Higashi,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +10 more
TL;DR: The data suggest that blockade of PDGF signaling pathways influences the interaction between bone marrow‐derived MSCs and tumor cells in the tumor microenvironment and, hence, inhibits the progressive growth of colon cancer.
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Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model.
Tomonori Sumida,Yasuhiko Kitadai,Kei Shinagawa,Miwako Tanaka,Michiyo Kodama,Mayu Ohnishi,Eiji Ohara,Shinji Tanaka,Wataru Yasui,Kazuaki Chayama +9 more
TL;DR: Administration of PDGF‐R tyrosine kinase inhibitor in combination with irinotecan appears to impair the progressive growth of gastric carcinoma by blockade of PD GF‐R signaling pathways in stromal cells.
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Antibodies to Helicobacter pylori and CagA protein are associated with the response to antibacterial therapy in patients with H. pylori-positive API2-MALT1-negative gastric MALT lymphoma.
Tomonori Sumida,Yasuhiko Kitadai,Toru Hiyama,Kei Shinagawa,Miwako Tanaka,Michiyo Kodama,Hiroshi Masuda,Masanori Ito,Shinji Tanaka,Masaharu Yoshihara,Kazuaki Chayama +10 more
TL;DR: Measurement of titers of serum antibodies to H. pylori and CagA protein may be useful for predicting the response to eradication therapy in patients with H.pylori‐positive API2–MALT1‐negative gastric MALT lymphoma.