T
Tomoyuki Shibata
Researcher at Massachusetts Institute of Technology
Publications - 53
Citations - 840
Tomoyuki Shibata is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Alkyl & Derivative (chemistry). The author has an hindex of 15, co-authored 53 publications receiving 836 citations. Previous affiliations of Tomoyuki Shibata include Daiichi Sankyo.
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Journal ArticleDOI
New ligands double the scope of the catalytic asymmetric dihydroxylation of olefins
K. Barry Sharpless,Willi Amberg,Matthias Beller,Hou Chen,Jens Hartung,Yasuhiro Kawanami,Doris Lubben,Eric Manoury,Yasukazu Ogino,Tomoyuki Shibata,Tatsuzo Ukita +10 more
TL;DR: Improved ligands render terminal olefins good substrates for the osmium-catalyzed asymmetric dihydroxylation (ADH) process as discussed by the authors.
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Syntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefins
Willi Amberg,Youssef L. Bennani,Raj K. Chadha,Gerard A. Crispino,William D. Davis,Jens Hartung,Kyu Sung Jeong,Yasukazu Ogino,Tomoyuki Shibata,K. Barry Sharpless +9 more
TL;DR: Experimental procedures for the preparation of two classes of derivatives of the cinchona alkaloids dihydroquinine and dihydronidine are described in this paper, where they serve as highly enantioselective ligands for the osmium tetraoxide catalyzed asymmetric dihydroxylation (AD) of olefins.
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Documenting the scope of the catalytic asymmetric dihydroxylation
B. Bhushan Lohray,Thomas H. Kalantar,B. Moon Kim,Christine Y. Park,Tomoyuki Shibata,Wai John S,K. Barry Sharpless +6 more
TL;DR: In this paper, a wide variety of functionalized and unfunctionalized olefins are efficiently converted to the corresponding cis vicinal diols in moderate to good enantiomeric excess via the "slow addition" enhanced catalytic asymmetric osmylation process.
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Synthetic study of 1-substituted carbapenem antibiotics
TL;DR: In this article, the total synthesis of 1-substituted carbapenems is described and the key step is the reaction of acetoxyazetidinone (7 ) with ketene silyl acetal (8 ).
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Ligand-based improvement of enantioselectivity in the catalytic asymmetric dihydroxylation of dialkyl substituted olefins
TL;DR: In this article, a high level of asymmetric induction was achieved in the asymmetric dihydroxylation of dialkyl substituted olefins using 9-O-aryldihydroquinidines as ligands.