T
Tomoyuki Tagami
Researcher at Kyoto University
Publications - 3
Citations - 3435
Tomoyuki Tagami is an academic researcher from Kyoto University. The author has contributed to research in topics: Arthritis & Autoimmune disease. The author has an hindex of 3, co-authored 3 publications receiving 3253 citations.
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Journal ArticleDOI
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
Takeshi Takahashi,Tomoyuki Tagami,Sayuri Yamazaki,Toshimitsu Uede,Jun Shimizu,Noriko Sakaguchi,Tak W. Mak,Shimon Sakaguchi +7 more
TL;DR: Interference with this role of CTLA-4 suffices to elicit autoimmune disease in otherwise normal animals, presumably through affecting CD25+CD4+ T cell–mediated control of self-reactive T cells.
Journal ArticleDOI
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
Noriko Sakaguchi,Takeshi Takahashi,Hiroshi Hata,Takashi Nomura,Tomoyuki Tagami,Sayuri Yamazaki,Toshiko Sakihama,Takaji Matsutani,Izumi Negishi,Syuichi Nakatsuru,Shimon Sakaguchi +10 more
TL;DR: It is shown that a spontaneous point mutation of the gene encoding an SH2 domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many aspects.
Journal ArticleDOI
A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
Hiroyuki Yoshitomi,Noriko Sakaguchi,Katsuya Kobayashi,Gordon D. Brown,Tomoyuki Tagami,Toshiko Sakihama,Keiji Hirota,Satoshi Tanaka,Takashi Nomura,Ichiro Miki,Siamon Gordon,Shizuo Akira,Takashi Nakamura,Shimon Sakaguchi +13 more
TL;DR: Specific microbes, including fungi and viruses, may evoke autoimmune arthritis such as rheumatoid arthritis by stimulating innate immunity in individuals who harbor potentially arthritogenic autoimmune T cells as a result of genetic anomalies or variations.