T
Tony Kiat Hon Lim
Researcher at Singapore General Hospital
Publications - 100
Citations - 4921
Tony Kiat Hon Lim is an academic researcher from Singapore General Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 25, co-authored 80 publications receiving 3114 citations. Previous affiliations of Tony Kiat Hon Lim include Agency for Science, Technology and Research & Genome Institute of Singapore.
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Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil
Zhengdeng Lei,Iain Beehuat Tan,Kakoli Das,Niantao Deng,Hermioni Zouridis,Sharon Pattison,Clarinda Chua,Zhu Feng,Yeoh Khay Guan,Chia Huey Ooi,Tatiana Ivanova,Shenli Zhang,Minghui Lee,Jeanie Wu,Anna Ngo,Sravanthy Manesh,Elisabeth Tan,Bin Tean Teh,Bin Tean Teh,Jimmy Bok Yan So,Liang Kee Goh,Alex Boussioutas,Tony Kiat Hon Lim,Horst Flotow,Patrick Tan,Steven G. Rozen +25 more
TL;DR: Based on gene expression patterns, gastric cancers are classified into 3 subtypes with differences in molecular and genetic features and response to therapy; this information might be used to select specific treatment approaches for patients with gastric cancer.
Journal ArticleDOI
Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency
Yannick Simoni,Michael G. Fehlings,Henrik N. Kløverpris,Naomi McGovern,Si-Lin Koo,Chiew Yee Loh,Shawn Lim,Ayako Kurioka,Joannah R. Fergusson,Choong-Leong Tang,Ming Hian Kam,Koh Dennis,Tony Kiat Hon Lim,Alexander Chung Yaw Fui,Chan Weng Hoong,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Maria A. Curotto de Lafaille,Maria A. Curotto de Lafaille,Sriram Narayanan,Sonia Baig,Muhammad Shabeer,Sue-Anne Ee Shiow Toh,Henry K.K. Tan,Rosslyn Anicete,Eng Huat Tan,Angela Takano,Paul Klenerman,Alasdair Leslie,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Florent Ginhoux,Evan W. Newell +35 more
TL;DR: The analysis shows that human ILCs are highly heterogeneous cell types between individuals and tissues, and provides a global, comprehensive, and detailed description of ILC heterogeneity in humans across patients and tissues.
Journal ArticleDOI
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre,Charles-Antoine Dutertre,Etienne Becht,Sergio Erdal Irac,Sergio Erdal Irac,Ahad Khalilnezhad,Ahad Khalilnezhad,Vipin Narang,Shabnam Khalilnezhad,Pei Y. Ng,Lucas L van den Hoogen,Jing Yao Leong,Bernett Lee,Marion Chevrier,Xiao Meng Zhang,Pearly Yong,Geraldine Koh,Josephine Lum,Shanshan W. Howland,Esther Wing Hei Mok,Jinmiao Chen,Anis Larbi,Henry K.K. Tan,Tony Kiat Hon Lim,Panagiota Karagianni,Athanasios G. Tzioufas,Benoit Malleret,Benoit Malleret,Joshua Brody,Salvatore Albani,Joel A G van Roon,Timothy R D J Radstake,Evan W. Newell,Florent Ginhoux,Florent Ginhoux +34 more
TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.
Journal ArticleDOI
Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy.
Wei Chang Colin Tan,Sanjna Nilesh Nerurkar,Hai Yun Cai,Harry Ho Man Ng,Harry Ho Man Ng,Duoduo Wu,Yu Ting Felicia Wee,Jeffrey Chun Tatt Lim,Joe Yeong,Joe Yeong,Joe Yeong,Tony Kiat Hon Lim +11 more
TL;DR: Various highly multiplexed techniques that have emerged to circumvent constraints, allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition, cellular functional and cell‐cell interactions are detailed.