Author
Toshifumi Inohara
Bio: Toshifumi Inohara is an academic researcher from Kyoto Pharmaceutical University. The author has contributed to research in topics: Coordination sphere & Vanadyl sulfate. The author has an hindex of 3, co-authored 3 publications receiving 156 citations.
Papers
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TL;DR: In this article, the new dioxo(semicarbazone)vanadium(V) complexes cis-VO2L have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin mimetic agents.
Abstract: The new dioxo(semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde semicarbazone (L1), salicylaldehyde 4-n-butylsemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
71 citations
TL;DR: Results indicate that the rational ligand design for VO complexes might be a promising approach to obtain superior insulinomimetic activity.
52 citations
TL;DR: This is the first finding on not only the insulinomimetic vanadyl-porphyrin complex but also the occurrence of a synergistic effect of VOTMpyP and sodium ascorbate to lower the high blood glucose levels in diabetic animals.
38 citations
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TL;DR: Recent trends in metal complexes include the use of chemically inert metal complexes as structural scaffolds for the design of enzyme inhibitors, new strategies for inducing selective coordination chemistry at the protein binding site, recent advances in the development of catalytic enzymes inhibitors, and theDesign of metal complexes that can inject electrons or holes into redox enzymes.
388 citations
TL;DR: The triazole Schiff bases and their oxovanadium(IV) complexes have been studied for in vitro antibacterial activity against four Gram-negative and two Gram-positive bacterial strains, in vitro antifungal activity against Trichophyton longifucus, Candida albican, Aspergillus flavus, Microscopum canis, Fusarium solani and Candida glaberata.
257 citations
TL;DR: In this paper, the authors focused on the interpenetrated 3D networks based on hydrogen-bonded metal-organic molecular (0D) and polymeric (1D and 2D) complexes from the Cambridge Structural Database.
Abstract: The occurrence of interpenetrated three-dimensional networks has been systematically investigated by the analysis of the crystallographic structural databases, using the program package TOPOS. After our previous reports on interpenetration observed in valence-bonded MOFs, inorganic arrays and hydrogen-bonded organic supramolecular architectures, in this paper we have focused our research on the interpenetrated 3D networks based on hydrogen-bonded metal–organic molecular (0D) and polymeric (1D and 2D) complexes from the Cambridge Structural Database. The current interest for the crystal engineering of new functional materials has prompted many research groups to adopt synthetic strategies implying the use of molecular metal complexes (0D) with suitably exo-oriented hydrogen-bond donor and acceptor groups for the assembly of extended networks. With regard to this we have examined 3D hydrogen-bonded supramolecular arrays formed by finite and infinite motifs of lower dimensionality, analyzing their topologies and looking for their entanglements. We have extracted a comprehensive list including 135 different motifs (71 assembled from 0D, 43 from 1D and 21 from 2D metal–organic motifs) showing the phenomenon of interpenetration (about two thirds not detected in the original papers). These hydrogen-bonded networks include species assembled by one or more building blocks, that are classified within the previously introduced Classes of interpenetration. It is observed that the maximum interpenetration degree is limited to 5-fold and the main (overall) topology is 412.63-pcu. An analysis of the possible relationships between the dimensionality of the building blocks and the resulting network connectivity and topology, and of some factors determining the interpenetration is also attempted, together with a comparison of the present results with those for other families of interpenetrated materials.
154 citations
TL;DR: The use of metals in therapeutic drugs has become increasingly important over the last couple of decades resulting in a variety of exciting and valuable drugs such as cisplatin and auranofin this paper.
145 citations
TL;DR: It was observed that "decavanadate" promote different effects than other vanadate oligomers in catalase activity, glutathione content, lipid peroxidation, mitochondrial superoxide anion production and vanadium accumulation, whereas both solutions seem to equally depress reactive oxygen species (ROS) production as well as total intracellular reducing power.
115 citations