T
Toshiro Kageshita
Researcher at Kumamoto University
Publications - 129
Citations - 5822
Toshiro Kageshita is an academic researcher from Kumamoto University. The author has contributed to research in topics: Melanoma & Monoclonal antibody. The author has an hindex of 30, co-authored 129 publications receiving 5580 citations. Previous affiliations of Toshiro Kageshita include New York Medical College.
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Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TL;DR: The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.
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Determinants of BRAF Mutations in Primary Melanomas
Janet L. Maldonado,Jane Fridlyand,Hetal N. Patel,Ajay N. Jain,Klaus J. Busam,Toshiro Kageshita,Tomomichi Ono,Donna G. Albertson,Daniel Pinkel,Boris C. Bastian +9 more
TL;DR: The uneven distribution of BRAF mutations strongly suggests distinct genetic pathways leading to melanoma, and the high mutation frequency in melanomas arising on intermittently sun-exposed skin suggests a complex causative role of such exposure that mandates further evaluation.
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Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression.
TL;DR: In this paper, the authors examined the expression of the proteasome subunits LMP2 and LMP7, the MHC-encoded transporter subunits TAP1 and TAP2, and HLA Class I antigens.
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Loss of β-catenin expression associated with disease progression in malignant melanoma
TL;DR: This work has shown that β‐catenin plays a crucial role in the function of cell adhesion molecules and also participates in growth regulatory signalling pathways that may be involved in malignant transformation.
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Purification of murine IgG monoclonal antibodies by precipitation with caprylic acid: comparison with other methods of purification.
TL;DR: It is noted that precipitation with caprylic acid is associated with a reduction in the affinity of some antibodies and is not suitable to purify murine IgA and IgG3, but superior to affinity chromatography on antibodies and to HPLC.