T
Toshiyuki Akiyama
Researcher at University of North Carolina at Chapel Hill
Publications - 20
Citations - 722
Toshiyuki Akiyama is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Xanthone & Podocarpus macrophyllus. The author has an hindex of 11, co-authored 19 publications receiving 635 citations. Previous affiliations of Toshiyuki Akiyama include Daiichi Sankyo.
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Recent advances in the investigation of curcuminoids
TL;DR: The literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant,Anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids are reviewed.
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Plant-derived natural product research aimed at new drug discovery.
TL;DR: Research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors’ laboratories as antitumor and anti-HIV clinical trial candidates are summarized.
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Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.
Yoshihisa Asada,Aya Sukemori,Takashi Watanabe,Kuber J. Malla,Takafumi Yoshikawa,Wei Li,Kazuo Koike,Chin Ho Chen,Toshiyuki Akiyama,Keduo Qian,Kyoko Nakagawa-Goto,Susan L. Morris-Natschke,Kuo Hsiung Lee +12 more
TL;DR: Three novel 1-alkyldaphnane-type diterpenes, stelleralides A-C (4-6), and five known compounds were isolated from the roots of Stellera chamaejasme L and showed potent anti-HIV activity.
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Antitumor Agents. 261. 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol as Antiangiogenic Agents and Total Assignment of 1H NMR Spectra#
Yoshihide Usami,Yi Nan Liu,An Shen Lin,Makro Shibano,Toshiyuki Akiyama,Hideji Itokawa,Susan L. Morris-Natschke,Kenneth F. Bastow,Ryoji Kasai,Kuo Hsiung Lee +9 more
TL;DR: This report is the first to completely assign the (1)H NMR signals of 2, together with correction of data for 1 from prior reports, and report the complete and unambiguous assignment of 1 and 2, based on analyses of 2D NMR spectra.
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Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme
Yoshihisa Asada,Aya Sukemori,Takashi Watanabe,Kuber J. Malla,Takafumi Yoshikawa,Wei Li,Xinzhu Kuang,Kazuo Koike,Chin Ho Chen,Toshiyuki Akiyama,Keduo Qian,Kyoko Nakagawa-Goto,Susan L. Morris-Natschke,Yan Lu,Kuo Hsiung Lee +14 more
TL;DR: Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme and represent promising new leads for development into anti-AIDS clinical trial candidates.