T
Travers Ching
Researcher at University of Hawaii at Manoa
Publications - 38
Citations - 3470
Travers Ching is an academic researcher from University of Hawaii at Manoa. The author has contributed to research in topics: Gene & DNA methylation. The author has an hindex of 18, co-authored 38 publications receiving 2619 citations. Previous affiliations of Travers Ching include University of Hawaii.
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Journal ArticleDOI
Opportunities and obstacles for deep learning in biology and medicine.
Travers Ching,Daniel Himmelstein,Brett K. Beaulieu-Jones,Alexandr A. Kalinin,Brian T. Do,Gregory P. Way,Enrico Ferrero,Paul-Michael Agapow,Michael Zietz,Michael M. Hoffman,Michael M. Hoffman,Wei Xie,Gail L. Rosen,Benjamin J. Lengerich,Johnny Israeli,Jack Lanchantin,Stephen Woloszynek,Anne E. Carpenter,Avanti Shrikumar,Jinbo Xu,Evan M. Cofer,Evan M. Cofer,Christopher A. Lavender,Srinivas C. Turaga,Amr Alexandari,Zhiyong Lu,David J. Harris,Dave DeCaprio,Yanjun Qi,Anshul Kundaje,Yifan Peng,Laura K. Wiley,Marwin H. S. Segler,Simina M. Boca,S. Joshua Swamidass,Austin Huang,Anthony Gitter,Anthony Gitter,Casey S. Greene +38 more
TL;DR: It is found that deep learning has yet to revolutionize biomedicine or definitively resolve any of the most pressing challenges in the field, but promising advances have been made on the prior state of the art.
Journal ArticleDOI
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Nicola Gagliani,Maria Carolina Amezcua Vesely,Andrea Iseppon,Leonie Brockmann,Hao Xu,Noah W. Palm,Marcel R. de Zoete,Paula Licona-Limón,Ricardo Paiva,Travers Ching,Casey T. Weaver,Xiaoyuan Zi,Xinghua Pan,Rong Fan,Lana X. Garmire,Matthew J. Cotton,Yotam Drier,Bradley E. Bernstein,Jens Geginat,Brigitta Stockinger,Enric Esplugues,Samuel Huber,Richard A. Flavell +22 more
TL;DR: Two new fate-mapping mouse models are used to show that CD4+ T cells that formerly expressed IL-17A go on to acquire an anti-inflammatory phenotype and suggest that Th17 cell instability and plasticity is a therapeutic opportunity for inflammatory diseases.
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Cox-nnet: An artificial neural network method for prognosis prediction of high-throughput omics data
TL;DR: A new ANN framework called Cox-nnet is developed to predict patient prognosis from high throughput transcriptomics data, with functional biological insights, which achieves the same or better predictive accuracy compared to other methods.
Journal ArticleDOI
Power analysis and sample size estimation for RNA-Seq differential expression
TL;DR: A power analysis tool is provided that captures the dispersion in the data and can serve as a practical reference under the budget constraint of RNA-Seq experiments and confirm a local optimal power is achievable for a given budget constraint.
Journal ArticleDOI
Single-Cell Transcriptomics Bioinformatics and Computational Challenges.
TL;DR: Current state-of-the-art bioinformatics tools and methods for scRNA-Seq analysis are reviewed, as well as addressing some critical analytical challenges that the field faces.