T
Trevor D. Lamb
Researcher at Australian National University
Publications - 102
Citations - 11245
Trevor D. Lamb is an academic researcher from Australian National University. The author has contributed to research in topics: Visual phototransduction & Rhodopsin. The author has an hindex of 47, co-authored 100 publications receiving 10487 citations. Previous affiliations of Trevor D. Lamb include Stanford University & University of Cambridge.
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Journal ArticleDOI
Responses of retinal rods to single photons.
TL;DR: Individual quantal responses exhibited a smooth shape very similar to that of the average quantal response, which suggests that a single photoisomerization releases many particles of transmitter and that radial diffusion of internal transmitter is not a major source of delay in the light response.
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Dark adaptation and the retinoid cycle of vision.
Trevor D. Lamb,Edward N. Pugh +1 more
TL;DR: A mathematical model that successfully describes a wide range of results in human and other mammals is presented, showing that the time-course of human dark adaptation and pigment regeneration is determined by the local concentration of 11-cis retinal, and that after a large bleach the recovery is limited by the rate at which 11-Cis Retinal is delivered to opsin in the bleached rod outer segments.
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Amplification and kinetics of the activation steps in phototransduction
Edward N. Pugh,Trevor D. Lamb +1 more
TL;DR: The investigation of amplification in the activation steps of vertebrate phototransduction shows that kcat/Km probably exceeds 10(7) M-1 s-1 (and is likely to be higher) in both amphibian and mammalian rods, and two different analyses based upon photocurrents were developed which provide lower bounds for kcat /Km in vivo.
Journal ArticleDOI
A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors.
Trevor D. Lamb,Edward N. Pugh +1 more
TL;DR: The model provides a comprehensive description of the activation steps of phototransduction at a molecular level and it is shown that the rising phase of the flash response is accurately described over a very wide range of intensities.
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G proteins and phototransduction.
TL;DR: How the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light is examined.