T
Trevor W. Robbins
Researcher at University of Cambridge
Publications - 1184
Citations - 177352
Trevor W. Robbins is an academic researcher from University of Cambridge. The author has contributed to research in topics: Prefrontal cortex & Cognition. The author has an hindex of 231, co-authored 1137 publications receiving 164437 citations. Previous affiliations of Trevor W. Robbins include Centre national de la recherche scientifique & Massachusetts Institute of Technology.
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Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer.
TL;DR: The dopamine-dependent locomotor-stimulant properties of intra-VTA infusions of opiates are associated with impaired conditioned reinforcer efficacy, and repeated stimulation of the mesoaccumbens dopamine pathway may compromise the dopamine-independence of the opiate system within the nucleus accumbens.
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Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis.
Anna O. Ermakova,Franziska Knolle,Azucena Justicia,Azucena Justicia,Edward T. Bullmore,Edward T. Bullmore,Peter B. Jones,Peter B. Jones,Trevor W. Robbins,Paul C. Fletcher,Graham K. Murray,Graham K. Murray +11 more
TL;DR: This study confirms that FEP patients have abnormal meso-cortical signalling of reward-Prediction errors, whereas reward-prediction-error dysfunction in the at-risk patients appears to show a more nuanced pattern of activation with a degree of midbrain impairment but preserved cortical function.
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Methamphetamine-induced disruption of frontostriatal reward learning signals: relation to psychotic symptoms.
Javier Bernacer,Philip R. Corlett,Pranathi Ramachandra,Brady McFarlane,Danielle C. Turner,Luke Clark,Trevor W. Robbins,Paul C. Fletcher,Graham K. Murray +8 more
TL;DR: It is demonstrated that methamphetamine impairs brain representations of computational parameters that underpin learning and demonstrates a significant link between psychosis and abnormal monoamine-regulated learning signals in the prefrontal and cingulate cortices.
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Dissociable effects of lesions to the dorsal or ventral noradrenergic bundle on the acquisition, performance, and extinction of aversive conditioning.
TL;DR: In six experiments, the effects of lesions to either the dorsal or ventral noradrenergic bundle on the acquisition and extinction of the conditioned emotional response (CER) as measured in a conditioned suppression paradigm were studied, with reference to Gray's "anxiety" and Mason's "selective attention" theories of locus coeruleus function.
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Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to D-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys.
Lawrence Stephen Wilkinson,Rebecca Dias,K. L. Thomas,Sarah J. Augood,Barry J. Everitt,Trevor W. Robbins,Angela C. Roberts +6 more
TL;DR: The effects of excitotoxic lesions of the prefrontal cortex on behavioural, neurochemical and molecular indices of dopamine function in the caudate nucleus were studied in the marmoset, indicating that following prefrontal manipulations, concurrence between behavioural and neurochemical indices of striatal dopamine function depends, critically, on the behavioural task.