T
Trevor W. Robbins
Researcher at University of Cambridge
Publications - 1184
Citations - 177352
Trevor W. Robbins is an academic researcher from University of Cambridge. The author has contributed to research in topics: Prefrontal cortex & Cognition. The author has an hindex of 231, co-authored 1137 publications receiving 164437 citations. Previous affiliations of Trevor W. Robbins include Centre national de la recherche scientifique & Massachusetts Institute of Technology.
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Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
TL;DR: The ability of amphetamine to decrease impulsivity is not solely due to its effects on dopaminergic systems, but may also depend on serotonergic neurotransmission.
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Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients
Zsuzsika Sjoerds,Zsuzsika Sjoerds,S. J. De Wit,W. van den Brink,Trevor W. Robbins,A.T.F. Beekman,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Dick J. Veltman,Dick J. Veltman +9 more
TL;DR: This is the first human study to provide experimental evidence for a disturbed balance between goal-directed and habitual control by use of an instrumental learning task, and to directly implicate cortical dysfunction to overreliance on inflexible habits in AD patients.
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Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.
TL;DR: It is suggested that, for different reasons, both the MS and OFC support behavioral flexibility after changes in reward contingencies, and are consistent with the hypothesis that striatal and OfC dysfunction can contribute to pathological perseveration.
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Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.
TL;DR: There is small but significant relationship between Val158Met genotype and executive function in healthy individuals but not in schizophrenia, and it is suggested that Val and Met alleles are codominant in their effects on cognition.
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Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: New evidence for central dopaminergic-noradrenergic interactions
TL;DR: Although DA and NA participate in qualitatively different behavioural processes, the effects of DNAB lesions on attentional processes depend on the level of DA activity within the nucleus accumbens, which is antagonised by systemic administration of the specific dopaminergic (DA) antagonist alpha-flupenthixol.